2. Immunology/Inflammation
  3. Interleukin Related
  4. Lokivetmab

Lokivetmab  (Synonyms: 洛吉维单抗; Anti-Canine IL31 Recombinant Antibody; CAN34D3-65; PF-06443537)

目录号: HY-P99301 纯度: ≥99.0%
COA 技术支持

Lokivetmab (Anti-Canine IL31 Recombinant Antibody) 是一种抗犬 IL-31 单克隆抗体。Lokivetmab 抑制 IL-31 介导的瘙痒信号在周围感觉神经元中的激活，并减轻 TH2 加权炎症。Lokivetmab 在控制犬特应性皮炎 (CAD) 的瘙痒和改善皮肤病变方面显示出长期疗效。Lokivetmab 可用于犬特应性皮炎 (AD) 的研究。

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CAS No. : 1533403-95-0

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规格 价格 是否有货 数量
1 mg ￥3000
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Lokivetmab 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody. Lokivetmab inhibits IL-31-mediated activation of pruritogenic signals in peripheral sensory neurons and reduces TH2-weighted inflammation. Lokivetmab demonstrates long-term efficacy in controlling pruritus and improving skin lesions in dogs with canine atopic dermatitis (CAD). Lokivetmab can be used for the research of atopic dermatitis (AD) in dogs[1].

同型

Caninized IgG2 kappa
反应种属

Caninized
IC50 & Target[1]

IL-31

 

体内研究
(In Vivo)

Lokivetmab (2 mg/kg, 静脉注射, 每 4-8 周一次, 持续 12 个月) 在控制犬只瘙痒和改善皮肤病变方面显示出长期疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Canine atopic dermatitis (CAD) dog model[1]
Dosage: 2 mg/kg
Administration: i.v. injection, every 4-8 weeks, 12 months
Result: Achieved pruritus control with 87% (64/75) of dogs maintaining PVAS below baseline.
Improved skin lesions with mean VetVAS (skin lesion score).
基因 ID

256353430  [NCBI]

Accession

BAH97742
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

147.51 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

洛吉维单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG2-kappa
Biological Activity
  • Immobilized IL-31 Protein, Canine (HEK293, His, HY-P703718) can bind Lokivetmab. The EC50 for this effect is 59.37 ng/mL.
纯度 & 产品资料
参考文献

Lokivetmab 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lokivetmab1533403-95-0Anti-Canine IL31 Recombinant Antibody CAN34D3-65 PF-06443537洛吉维单抗PF06443537PF 06443537PF-06443537Interleukin RelatedILatopic dermatitiscanineIL-31Inhibitorinhibitorinhibit

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目录号：
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