Lomefloxacin hydrochloride  (Synonyms: 盐酸洛美沙星; SC47111A hydrochloride; NY-198 hydrochloride)

Lomefloxacin hydrochloride (NY-198 hydrochloride) is an orally active difluoroquinolone antibiotic. Lomefloxacin hydrochloride prevents DNA supercoiling and replication by inhibiting bacterial topoisomerase II. Lomefloxacin hydrochloride induces ROS production and Apoptosis. Lomefloxacin hydrochloride has broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria. Lomefloxacin hydrochloride has anticancer effects against melanoma. Lomefloxacin hydrochloride can be used in the study of systemic bacterial infections (such as Salmonella typhimurium infections), skin and melanoma ^{[1][2][3][4][5][6]}.

Lomefloxacin (1/4 至 2×MIC 浓度) hydrochloride 可迅速降低金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌的活菌数量，除 P. aeruginosa 外，所有菌株均未观察到再生长^[1]。
Lomefloxacin 在对大肠杆菌和金黄色葡萄球菌等菌株的敏感性测定实验中，显示范围为 0.06-4 μg/mL 的 MIC 值^[2]。
Lomefloxacin (0.1-1.0 mM；24-72 h) 可降低 COLO829 细胞活力，并诱导 COLO829 细胞中 ROS 的产生^[3]。
Lomefloxacin ( 50-100 μM）可诱导角质形成细胞凋亡^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lomefloxacin (ED₅₀：1.45-32.2 mg/kg；口服；感染后立即给药) hydrochloride 显著降低腹膜内感染小鼠的死亡率，ED₅₀值低于氧氟沙星和诺氟沙星^[1]。
Lomefloxacin (-80 mg/kg；口胃给药) hydrochloride 可降低感染鼠伤寒沙门氏菌小鼠的死亡率，显著降低脾脏细菌数量，并抑制炎症反应^[5]。
Lomefloxacin (16-32 mg/kg；腹腔注射；5 天) hydrochloride 仅在最高剂量下略微减少小鼠交配第三周的着床数和活胎数，且未发现诱导显著的显性致死突变^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

387.81

C₁₇H₂₀ClF₂N₃O₃

98079-52-8

固体

White to off-white

盐酸洛美沙星

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Hirose T, et al. In vitro and in vivo activity of NY-198, a new difluorinated quinolone. Antimicrob Agents Chemother. 1987 Jun;31(6):854-9.  [Content Brief]

  [2]. Piddock LJ, et al. Mechanism of action of lomefloxacin. Antimicrob Agents Chemother. 1990 Jun;34(6):1088-93.  [Content Brief]

  [3]. Beberok A, et al. Lomefloxacin Induces Oxidative Stress and Apoptosis in COLO829 Melanoma Cells. Int J Mol Sci. 2017 Oct 20;18(10):2194.  [Content Brief]

  [4]. Marrot L, et al. Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis. J Invest Dermatol. 2003 Sep;121(3):596-606.  [Content Brief]

  [5]. Butler T, et al. Treatment of experimental Salmonella typhimurium infection in mice with lomefloxacin. J Antimicrob Chemother. 1990 Apr;25(4):629-34.  [Content Brief]

  [6]. Singh AC, et al. Genotoxicity of lomefloxacin--an antibacterial drug in somatic and germ cells of Swiss albino mice in vivo. Mutat Res. 2003 Feb 5;535(1):35-42.  [Content Brief]