2. Neuronal Signaling GPCR/G Protein Stem Cell/Wnt Cytoskeleton
  3. Monoamine Oxidase Guanylate Cyclase PKG Collagen
  4. LOXL2/sGC modulator-2

LOXL2/sGC modulator-2 (Compound 9k) 是一种选择性且具有口服活性的赖氨酰氧化酶样蛋白 2 (LOXL2) 和可溶性鸟苷酸环化酶 (sGC) 双靶点调节剂。LOXL2/sGC modulator-2 对 LOXL2 具有抑制活性，其 IC50 值为 0.1 μM，并能够激活 sGC。LOXL2/sGC modulator-2 可改善血管重构并降低肺动脉压。LOXL2/sGC modulator-2 能够下调 PKG1、PCNA、α-SMA、collagen I 和 fibronectin 的水平。LOXL2/sGC modulator-2 可用于肺动脉高压的研究。

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LOXL2/sGC modulator-2

LOXL2/sGC modulator-2 Chemical Structure

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LOXL2/sGC modulator-2 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

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MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LOXL2/sGC modulator-2 (Compound 9k) is a selective and orally active lysyl oxidase-like 2 (LOXL2) and soluble guanylate cyclase (sGC) dual-target regulator. LOXL2/sGC modulator-2 shows inhibitory activity for LOXL2 with an IC50 of 0.1 μM and can activate sGC. LOXL2/sGC modulator-2 can ameliorate vascular remodeling and reduce pulmonary artery pressure. LOXL2/sGC modulator-2 can downregulate PKG1, PCNA, α-SMA, collagen I and fibronectin levels. LOXL2/sGC modulator-2 can be used for the research of pulmonary arterial hypertension [1].

分子量

487.47

Formula

C25H24F3N3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LOXL2/sGC modulator-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LOXL2/sGC modulator-2Monoamine OxidaseGuanylate CyclasePKGCollagenMAOcGMP-dependent protein kinaseInhibitorinhibitorinhibit

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