2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. LT-850-166

LT-850-166 是一种有效的 FLT3 抑制剂，具有克服多种 FLT3 突变的能力。

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LT-850-166

LT-850-166 Chemical Structure

CAS No. : 3031480-22-2

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LT-850-166 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LT-850-166 is a potent FLT3 inhibitor with the capacity of overcoming a variety of FLT3 mutations.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3663 nM
Compound: 67
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
BaF3 IC50
4095 nM
Compound: 67
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
BaF3 IC50
42.4 nM
Compound: 67
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-N676D mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-N676D mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
BaF3 IC50
7.6 nM
Compound: 67
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
BaF3 IC50
8.3 nM
Compound: 67
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-F691L mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-F691L mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
BaF3 IC50
< 1.5 nM
Compound: 67
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
BaF3 IC50
< 1.5 nM
Compound: 67
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-Y842H mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-Y842H mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
BaF3 IC50
< 1.5 nM
Compound: 67
Antiproliferative activity against mouse BaF3 cells harboring FLT3-TEL-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse BaF3 cells harboring FLT3-TEL-D835V mutant assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
HCT-116 IC50
> 10000 nM
Compound: 67
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
MDA-MB-231 IC50
3853 nM
Compound: 67
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
MKN-45 IC50
4029 nM
Compound: 67
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
MOLM-13 IC50
9.85 nM
Compound: 67
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
MV4-11 IC50
2.93 nM
Compound: 67
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
NB-4 IC50
> 5000 nM
Compound: 67
Antiproliferative activity against human NB-4 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human NB-4 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
Panc02 IC50
2745 nM
Compound: 67
Antiproliferative activity against mouse Panc02 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against mouse Panc02 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
THP-1 IC50
> 5000 nM
Compound: 67
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
U-937 IC50
> 2000 nM
Compound: 67
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured after 72 hrs by CellTiterGlo luminescent assay
[PMID: 34550682]
分子量

574.50

Formula

C30H29Cl2N7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LT-850-166 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LT-850-1663031480-22-2FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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