2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. LTK-14A

LTK-14A 是 Garcinol (HY-107569) 的衍生物，是一种选择性组蛋白丁酰化 (histone butyrylation) 抑制剂。LTK-14A 不影响乙酰化。LTK-14A 可显著抑制 H4K5 的丁酰化，并下调促脂肪生成基因的表达，最终导致脂肪生成被抑制。LTK-14A 可用于肥胖症的研究。

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LTK-14A

LTK-14A Chemical Structure

CAS No. : 71118-00-8

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LTK-14A 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LTK-14A, a derivative of Garcinol (HY-107569), is a selective histone butyrylation inhibitor. LTK-14A does not affect acetylation. LTK-14A significantly inhibits the butyrylation of H4K5 and downregulated the expression of proadipogenic genes, thus culminating in abolished adipogenesis. LTK-14A can be used for the study of obesity[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 20 μM
Compound: 6b
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 30500683]
HEL IC50
> 20 μM
Compound: 6b
Antiproliferative activity against HEL cells after 72 hrs by MTT assay
Antiproliferative activity against HEL cells after 72 hrs by MTT assay
[PMID: 30500683]
HeLa IC50
19.68 μM
Compound: 6b
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay
[PMID: 30500683]
K562 IC50
> 20 μM
Compound: 6b
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
Antiproliferative activity against human K562 cells after 72 hrs by MTT assay
[PMID: 30500683]
MCF7 IC50
> 20 μM
Compound: 6b
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 30500683]
分子量

630.85

Formula

C40H54O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LTK-14A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LTK-14A71118-00-8HDACHistone deacetylasesH4K5histone butyrylationacetylationproadipogenic genesadipogenesisobesityInhibitorinhibitorinhibit

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产品名称：
LTK-14A
目录号：
HY-160461
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