2. Anti-infection
  3. Bacterial
  4. Lug-15

Lug-15 是一种快速杀菌剂。Lug-15 对多种革兰氏阳性菌和革兰氏阴性菌，包括耐药菌株，表现出强大的抗菌活性。Lug-15 能迅速消灭细菌，其主要机制是破坏细菌的细胞膜，并且耐药性诱导倾向极低。Lug-15 具有较低的溶血毒性，并在多种感染模型中显示出显著疗效。Lug-15 可用于研究抗多重耐药感染。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lug-15

Lug-15 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Lug-15 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lug-15 is a rapid bactericidal agent. Lug-15 exhibits strong antibacterial activity against both Gram-positive and Gram-negative bacteria, including drug-resistant strains. Lug-15 rapidly kills bacteria primarily through membrane disruption and had a very low propensity to induce bacterial resistance. Lug-15 demonstrates low hemolytic toxicity and significant therapeutic potential in various infection models. Lug-15 can be used for research on combating infections caused by multi-drug resistant bacteria[1].

体外研究
(In Vitro)

Lug-15 对革兰氏阳性菌和革兰氏阴性菌均表现出强效抗菌活性，其 MIC 分别为：金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌 (MRSA) 为 3.13 μg/mL，鸡肠球菌为 6.25 μg/mL，铜绿假单胞菌、鲍曼不动杆菌和大肠杆菌为 12.5 μg/mL[1]。
Lug-15 (2 × MIC, 0-12 h) 可降低金黄色葡萄球菌和鸡肠球菌的菌落形成单位，并使大肠杆菌计数在 4 小时内从 10^5.5 CFU/mL 降至 0[1]。
Lug-15 (0.5-4 × MIC, 0.5-1 h) 破坏了金黄色葡萄球菌和大肠杆菌的细菌外膜/内膜的完整性，并损伤了大肠杆菌的内膜，导致细胞膜的不可逆损伤[1]。
Lug-15 (0.5-4 × MIC, 4 h) 显著降低了细菌细胞内的 ATP 含量，并导致金黄色葡萄球菌中 ROS 水平呈浓度依赖性显著升高[1]。
Lug-15 (0.5 × MIC, 传代 21 次) 极难诱导金黄色葡萄球菌的增殖。金黄色葡萄球菌产生耐药性[1]。
Lug-15 (6.25-200 μg/mL, 1 h) 在有效抗菌浓度下对大鼠红细胞的溶血率低于 10%[1]。
Lug-15 (0-48 h) 在哺乳动物血清中具有良好的稳定性，并能在复杂的生理环境下保持其抗菌活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lug-15 相关抗体:
体内研究
(In Vivo)

Lug-15 (1 mg/mL，滴眼，多次使用) 可有效治疗小鼠眼部耐甲氧西林金黄色葡萄球菌 (MRSA) 或铜绿假单胞菌感染[1]。
Lug-15 (5-15 mg/kg，腹腔注射或局部使用水凝胶，单次给药或 2-4 次给药) 在 MRSA 感染小鼠大腿、肺部和伤口模型中均显示出显著疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Keratitis Model infected with MRSA or P. aeruginosa established in six-week-old female Kunming mice (weighing 20-22 g)[1]
Dosage: 1 mg/mL
Administration: Eye drops, multiple times
Result: Reduced the bacterial load in the eyes, and the appearance of the eyeball becomed clearer.
Significantly reduced the infiltration of inflammatory cells.
Animal Model: Neutropenic thigh infection model and pneumonia model established in six-week-old female Kunming mice (weighing 20-22 g)[1]
Dosage: 15 (Neutropenic thigh infection) and 5 mg/kg (pneumonia infection)
Administration: Intraperitoneal injection (i.p.), 4 doses (Neutropenic thigh infection) and 2 doses (pneumonia infection)
Result: Significantly inhibited the spread of infection, and the bacterial load in the thigh tissue was significantly reduced.
Reduced pulmonary congestion and the bacterial load in the lungs, and lowered the levels of inflammatory factors and pathological damage.
分子量

1120.42

Formula

C56H81N17O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lug-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lug-15Lug15Lug 15BacterialLugduninAntimicrobial resistanceMembrane disruptionAntibioticsIn vivo therapeutic efficacyInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Lug-15
目录号：
HY-178504
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z