2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR
  4. LXR agonist 4

LXR agonist 4 是一种选择性 LXR 反向激动剂，其 IC50 值分别为 7.6 μM (LXRα) 和 2.9 μM (LXRβ)。LXR agonist 4 对 RORα 和 FXR 表现出选择性。LXR agonist 4 能显著抑制 SREBP1c 的表达，且不影响 ABCA1 或 APOE 的表达。LXR agonist 4 具有抗脂肪生成特性，并能消除脂肪酸诱导的脂肪变性。LXR agonist 4 可用于动脉粥样硬化和代谢功能障碍相关脂肪肝 (MASLD) 的研究。

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LXR agonist 4

LXR agonist 4 Chemical Structure

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LXR agonist 4 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LXR agonist 4 is a selective LXR inverse agonist with IC50 values of 7.6 (LXRα) and 2.9 μM (LXRβ), respectively. LXR agonist 4 exhibits selectivity over RORα and FXR. LXR agonist 4 robustly suppresses SREBP1c expression without altering ABCA1 or APOE. LXR agonist 4 displays antilipogenic properties and resolves fatty acid-induced steatosis. LXR agonist 4 can be used for the research of atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD)[1].

IC50 & Target[1]

LXRα

7.6 μM (IC50)

LXRβ

2.9 μM (IC50)

体外研究
(In Vitro)

LXR agonist 4 (compound 3) (30 μM; 4-24 小时) 不抑制 HEK293T 或 HepG2 细胞的增殖[1]。
LXR agonist 4 (30 μM; 24 小时) 抑制 HepG2 细胞中 SREBP1c 的表达，而不改变 ABCA1 或 APOE[1]。
LXR agonist 4 (30 μM; 72 小时) 表现出抗脂肪生成特性，并能消除 HepG2 细胞中脂肪酸诱导的脂肪变性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LXR agonist 4 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HEK293T and HepG2
Concentration: 30 μM
Incubation Time: 4, 14, and 24 h
Result: Showed no significant inhibition of proliferation in HEK293T and HepG2 cells over 24 hours.
分子量

634.15

Formula

C36H31ClF3NO2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LXR agonist 4 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LXR agonist 4LXR agonist4LXR agonist-4LXRLiver X receptorLXRαLXRβSREBP1cantilipogenicfatty acid-induced steatosisatherosclerosismetabolic dysfunction-associated steatotic liver diseaseInhibitorinhibitorinhibit

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