2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. LY 78335

LY 78335 (DCMB)，一种可穿透血脑屏障的苯乙醇胺-N-甲基转移酶 (PNMT) 抑制剂，其 Ki 为 0.09 μM。LY 78335 作为 α₂-肾上腺素能受体 (α₂-adrenoceptor) 抑制剂，其 IC50 为 10 μM。LY 78335 可增加大鼠的自发运动活动。LY 78335 可提高大鼠下丘脑中 3-甲氧基-4-羟基苯基甘醇 (MHPG) 的细胞外浓度。LY 78335 可抑制大鼠生长激素 (GH) 分泌。LY 78335 可用于抑郁症研究。

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LY 78335

LY 78335 Chemical Structure

CAS No. : 39226-94-3

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规格 价格 是否有货 数量
50 mg ￥494
In-stock
100 mg ￥760
In-stock
250 mg ￥1292
In-stock
500 mg ￥1900
In-stock
1 g ￥2774
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LY 78335 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY 78335 (DCMB) is a brain-penetrant phenylethanolamine-N-methyltransferase (PNMT) inhibitor with a Ki of 0.09 μM. LY 78335 acts as an α₂-adrenoceptor inhibitor with an IC50 of 10 μM. LY 78335 increases spontaneous locomotor activity in rats. LY 78335 increases extracellular concentration of 3-methoxy-4-hydroxyphenylglycol (MHPG) in rat hypothalamus. LY 78335 prevents growth hormone (GH) secretion in rats. LY 78335 can be used for the research of depression[1].

IC50 & Target[1]

Phenylethanolamine-N-methyltransferase (PNMT)

0.09 μM (Ki)

α2-adrenergic receptor

10 μM (IC50)

体内研究
(In Vivo)

LY 78335 (DCMB) (50 mg/kg; i.p.) 可抑制大鼠下丘脑内的 α2-肾上腺素能受体功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, 10-week-old, initially 8-week-old, fed for 2 weeks before experiments)[1]
Dosage: 50 mg/kg
Administration: i.p.; single dose
Result: Increased spontaneous locomotor activity; increased extracellular MHPG concentration in the hypothalamus; blocked clonidine-induced GH secretion.
分子量

190.07

Formula

C8H9Cl2N
CAS 号
性状

液体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

LY 78335 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY 7833539226-94-3DCMBLY78335LY-78335Adrenergic ReceptorBeta Receptorgrowth hormoneα?-adrenoceptorMHPGGHrat hypothalamusblood-brain barrierphenylethanolamine-N-methyltransferase3-methoxy-4-hydroxyphenylglycolratsPNMTInhibitorinhibitorinhibit

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HY-142110
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