2. Immunology/Inflammation
  3. CD19
  4. LY3541860

LY3541860 是一种选择性抗 CD19 抗体，既能以高亲和力结合人 CD19，又能选择性结合人 B 细胞 (人和食蟹猴的 Kd 值分别为 76.8 pM 和 94.5 nM)。LY3541860 可抑制 CpG 诱导的 CD69 表达 (IC50 = 0.006 nM)。LY3541860 表现出强效的 B 细胞抑制活性。LY3541860 可抑制 BCR 和 TLR 诱导的人 B 细胞活化。LY3541860 可用于自身免疫性疾病的研究。

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LY3541860

LY3541860 Chemical Structure

1.  客户无需承担相应的运输费用。

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LY3541860 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY3541860 is a selective anti-CD19 antibody that both binds human CD19 with high affinity and selectively binds human B cells (Kd values: 76.8 pM and 94.5 nM for humans and cynomolgus monkeys, respectively). LY3541860 inhibits CpG-induced CD69 expression (IC50 = 0.006 nM). LY3541860 exhibits potent B cell inhibitory activities. LY3541860 can inhibit both BCR- and TLR-induced human B cell activation. LY3541860 can be used for the research of autoimmune diseases[1].

反应种属

Human
IC50 & Target

CD19
体外研究
(In Vitro)

LY3541860 (1.6-1000 nM) 以高亲和力结合人及食蟹猴 CD19 (Kd 值分别为：76.8 pM、94.5 nM)[1]。
LY3541860 (30 分钟) 可选择性结合全血中的人 B 细胞 (EC50 = 0.184 nM)[1]。
LY3541860 (0.001 nM-10 nM；30 分钟) 可抑制 B 细胞增殖 (IC50 = 0.008 nM)[1]。
LY3541860 (0.1 pM-10 nM) 可抑制 CpG 诱导的 CD69 表达 (IC50 = 0.006 nM)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY3541860 相关抗体:
体内研究
(In Vivo)

LY3541860 (0.01-1.0 mg/kg；皮下注射；每周一次) 可抑制雌性人源化 NSG 小鼠的 B 细胞活化和免疫球蛋白分泌 (人 IgM 分泌减少 57-78%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (female, humanized with PBMC engraftment)[1]
Dosage: 0.01 mg/kg (IgM secretion attenuation); 1.0 mg/kg (IgM secretion attenuation and CD86 expression reduction)
Administration: s.c.; weekly
Result: Attenuated human IgM secretion by 60% on day 6 and 57% on day 10 at 0.01 mg/kg/week; attenuated IgM secretion by 78% on day 6 and 57% on day 10 at 1.0 mg/kg/week; reduced CD86 expression on human B cells in spleens dose-dependently
基因 ID

930  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY3541860 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY3541860LY 3541860LY-3541860CD19AKT1humanized miceERK1/2B cell proliferationB cell differentiationWil2-s cellsBCR cappingprimary human B cellsB cell activationInhibitorinhibitorinhibit

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