2. Anti-infection Immunology/Inflammation
  3. Bacterial Toll-like Receptor (TLR)
  4. Lytx-Pa2a

Lytx-Pa2a  (Synonyms: Lycotoxin-Pa2a; TBIU041425)

目录号: HY-P11442
产品使用指南 技术支持

Lytx-Pa2a (Lycotoxin-Pa2a) 是一种靶向细菌细胞膜 (bacterial membranes) 和 TLR4 受体 (TLR4 receptor) 的肽类抑制剂。Lytx-Pa2a 通过非竞争性破坏细胞外/细胞质膜来发挥抗菌作用以及抑制 LPS 诱导的 TLR4/NF-κB 信号通路。Lytx-Pa2a 有望用于细菌感染和炎症相关疾病 (如败血症) 的研究。

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Custom Peptide Synthesis

Lytx-Pa2a

Lytx-Pa2a Chemical Structure

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规格 是否有货
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Lytx-Pa2a 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lytx-Pa2a (Lycotoxin-Pa2a) is a peptide inhibitor against bacterial membranes and TLR4 receptor. Lytx-Pa2a exerts antimicrobial effects via non-competitive disruption of outer/cytoplasmic membranes and suppression of LPS-induced TLR4/NF-κB signaling. Lytx-Pa2a is promising for research of bacterial infection and inflammation-related disease (e.g., sepsis)[1].

IC50 & Target

TLR4

 

分子量

7298.38

Formula

C314H494N94O91S8
Sequence

Lys-Glu-Cys-Ile-Pro-Lys-His-His-Glu-Cys-Thr-Ser-Asn-Lys-Lys-Gly-Cys-Cys-Arg-Gly-Lys-Leu-Phe-Lys-Tyr-Lys-Cys-Gln-Cys-Thr-Thr-Val-Val-Asp-Gln-Ser-Gly-Glu-Gln-Ala-Glu-Arg-Cys-Phe-Cys-Gly-Thr-Ala-Thr-His-His-Lys-Ala-Ala-Glu-Leu-Val-Val-Gly-Phe-Gly-Lys-Lys-Leu-Phe-Gly (disulfide bridge:Cys3-Cys18,Cys10-Cys27,Cys17-Cys45,Cys29-Cys43)
Sequence Shortening

KECIPKHHECTSNKKGCCRGKLFKYKCQCTTVVDQSGEQAERCFCGTATHHKAAELVVGFGKKLFG (disulfide bridge:Cys3-Cys18,Cys10-Cys27,Cys17-Cys45,Cys29-Cys43)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lytx-Pa2a 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lytx-Pa2aLycotoxin-Pa2a TBIU041425TBIU041425TBIU 041425TBIU-041425BacterialToll-like Receptor (TLR)bacterial membranesTLR4 receptorinflammation-related diseaseInhibitorinhibitorinhibit

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目录号：
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