2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. M3 mAChR agonist 1

M3 mAChR agonist 1 是一种优先作用于 M3 亚型的 M3/M5 mAChR 双重正向变构调节剂 (PAM)。M3 mAChR agonist 1 对包括 M1、M2 和 M4 mAChR 在内的其他 mAChR 亚型具有优异的亚型选择性。M3 mAChR agonist 1 通过调节 M3 毒蕈碱乙酰胆碱受体，增加离体大鼠膀胱条的收缩，从而增强信号通路。

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M3 mAChR agonist 1

M3 mAChR agonist 1 Chemical Structure

CAS No. : 1624297-26-2

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M3 mAChR agonist 1 相关抗体

Top Publications Citing Use of Products

查看 mAChR 亚型特异性产品:

查看所有亚型
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

M3 mAChR agonist 1 is an M3-preferring M3/M5 mAChR dual positive allosteric modulators (PAM). M3 mAChR agonist 1 shows excellent subtype selectivity over other subtypes of mAChRs including M1, M2, and M4 mAChRs. M3 mAChR agonist 1 increases the contraction of isolated rat bladder strips by modulating the M3 muscarinic acetylcholine receptor, leading to enhanced signaling pathways. M3 mAChR agonist 1 can be used for the research of endocrinology[1].

IC50 & Target[1]

mAChR3

 

mAChR5

 

体外研究
(In Vitro)

M3 mAChR agonist 1 (compound 9; 1-10 µM) 可增强电场刺激 (EFS) 下神经释放的 ACh 的作用，从而导致离体大鼠膀胱条收缩增强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

M3 mAChR agonist 1 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route AUC0-inf T1/2 CLtotal Vss Cmax Tmax F
Rat[1] 0.3 mg/kg i.v. 330.2 ng·h/mL 2.43 h 917.7 mL/h/kg 1.59 L/kg / / /
Rat[1] 1 mg/kg p.o. 208.8 ng·h/mL 2.16 h / / 85.29 ng/mL 0.31 h 19 %
分子量

618.67

Formula

C29H33F3N6O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

M3 mAChR agonist 1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M3 mAChR agonist 11624297-26-2mAChRMuscarinic acetylcholine receptorM3 muscarinic acetylcholine receptorsmooth muscleInhibitorinhibitorinhibit

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产品名称：
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