2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Anaplastic lymphoma kinase (ALK)
  4. M4K3250

M4K3250 是一种选择性的 ALK2 PROTAC 降解剂，其 pDC50 为 7.9。M4K3250 可诱导 ALK2 与 E3 泛素连接酶 CRBN 形成三元复合物，进而导致 ALK2 降解并抑制 ALK2 的活性。M4K3250 在胶质母细胞瘤细胞中表现出细胞毒性。M4K3250 可用于胶质母细胞瘤的相关研究。
(粉色: ALK2 靶蛋白配体；蓝色: Cereblon 配体 (HY-14658)；黑色: 连接子)。

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M4K3250

M4K3250 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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M4K3250 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

M4K3250 is a selective ALK2 PROTAC degrader with a pDC50 of 7.9. M4K3250 induces the formation of a ternary complex between ALK2 and the E3 ubiquitin ligase CRBN, thereby causing ALK2 degradation and inhibiting ALK2 activity. M4K3250 exhibits cytotoxicity in glioblastoma cells. M4K3250 can be used in studies related to glioblastoma[1]. (Pink: ALK2 Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker).

IC50 & Target[1]

Cereblon

 

体外研究
(In Vitro)

M4K3250 (4 h) 在 HEK-293 细胞中诱导 ALK2 与 CRBN 形成三元复合物，其 pEC50 为 6.9[1]。
M4K3250 (0-30 μM; 96 h) 以剂量依赖性方式降低 U87-MG 胶质母细胞瘤细胞的活力，且该效应不依赖于 CRBN 介导的 ALK2 降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

M4K3250 相关抗体:
分子量

760.85

Formula

C43H45FN6O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

M4K3250 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M4K3250PROTACsAnaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246human liver microsomesU87-MG glioblastoma cellACVR1/ALK2E3 ubiquitin ligase CRBNmouse liver microsomesActivin Receptor-like Kinase 2HEK-293 cellsALK5glioblastoma cellsInhibitorinhibitorinhibit

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目录号：
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