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  4. Magnesium sulfate

Magnesium sulfate  (Synonyms: 硫酸镁)

目录号: HY-Y1267 含量: 99.07%
COA 产品使用指南 技术支持

Magnesium sulfate 是一种钙拮抗剂和有效的 L 型钙通道抑制剂，也是一种宫缩抑制剂。Magnesium sulfate 具有抗炎、抗惊厥、血管舒张和神经保护的作用。Magnesium sulfate 可用于先兆子痫/子痫等疾病的研究。

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Magnesium sulfate

Magnesium sulfate Chemical Structure

CAS No. : 7487-88-9

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Magnesium sulfate 相关抗体

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Phospholipase A PLD Phospholipase C

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  • 参考文献

生物活性

Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a tocolytic. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in the research of diseases such as preeclampsia/eclampsia[1][2][3][4][5][6].

体外研究
(In Vitro)

Magnesium sulfate (3 mM) 可抑制培养的子宫肌层细胞中磷脂酰肌醇-4,5-二磷酸特异性磷脂酶 C 活性和随后的钙释放[2]。
Magnesium sulfate (20 mM; 6 小时) 可抑制 RAW264.7 细胞中 LPS (HY-D1056) 诱导的炎症分子的产生和 NF-κB 的活化[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Magnesium sulfate 相关抗体:

Real Time qPCR[3]

Cell Line: RAW264.7 cells treated with 100 ng/mL of LPS (HY-D1056)
Concentration: 20 mM
Incubation Time: 6 h
Result: Inhibtied the levels of iNOS and COX-2.
体内研究
(In Vivo)

Magnesium sulfate (腹腔注射; 270 mg/kg, 随后每 20 分钟注射 27 mg/kg, 持续 4 小时, 最后再注射 270 mg/kg) 可减轻 LPS (HY-D1056) 引起的胎鼠炎症相关脑损伤[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 out-bred timed pregnant mice, and intrauterine inflammation was induced by intrauterine injection of LPS (HY-D1056) on embryonic day 15[4]
Dosage: 270 mg/kg, followed by 27 mg/kg every 20 minutes for 4 hours, and then an additional 270 mg/kg
Administration: Intraperitoneal injection
Result: Prevented LPS-induced neuronal injury in fetal mouse brains, as evidenced by maintaining normal neuronal morphology, including dendritic processes and MAP2 staining, without significantly affecting the expression of proinflammatory cytokines or cell death markers.
CAS 号
性状

固体

颜色

White to off-white

中文名称

硫酸镁
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 25 mg/mL (超声助溶)

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This equation is commonly abbreviated as: C1V1 = C2V2

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纯度 & 产品资料

纯度: 99.63%

COA (265 KB)

产品使用指南 (1538 KB)
参考文献

Magnesium sulfate 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Magnesium7487-88-9硫酸镁Biochemical Assay ReagentsCalcium ChannelInterleukin RelatedNO SynthaseCOXNF-κBPhospholipaseCa2+ channelsCa channelsILNitric oxide synthasesNOSCyclooxygenaseNuclear factor-κBNuclear factor-kappaBInorganic saltmyometrial cellsRAW264.7 cellsLPSInhibitorinhibitorinhibit

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