2. Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Monoamine Oxidase Reactive Oxygen Species (ROS)
  4. MAO-B-IN-49

MAO-B-IN-49 是一种选择性，可逆的 MAO-B 抑制剂（对人 MAO-B 的 IC50 为 1 nM）。MAO-B-IN-49 对 MAO-B 的选择性远高于对 MAO-A 的选择性 (IC50 = 633.9)。MAO-B-IN-49 可降低脂多糖 (HY-D1056) (LPS) 在 HT22 细胞中诱导的 ROS 产生。MAO-B-IN-49 具有显著的神经保护作用，并能显著改善 MPTP (HY-W114750) 诱导的帕金森病 (PD) 小鼠模型的运动功能障碍。MAO-B-IN-49 可用于帕金森病的研究。

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MAO-B-IN-49

MAO-B-IN-49 Chemical Structure

CAS No. : 3098883-91-8

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MAO-B-IN-49 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (HY-D1056) (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750)-induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD[1].

体外研究
(In Vitro)

MAO-B-IN-49 (Compound ZM24) (2-50 μM，24 小时) 在 HT22 细胞中所有测试条件下均表现出超过 75% 的细胞活力[1]。
MAO-B-IN-49 (5-20 μM，24 小时) 将细胞与不同浓度的药物共孵育后，HT22 细胞中脂多糖 (LPS) 诱导的 ROS 生成显著降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-49 相关抗体:

Cell Viability Assay

Cell Line: HT22 hippocampal neuronal cell line
Concentration: 2 μM, 5 μM, 10 μM, 20μM, 50 μM
Incubation Time: 24 h
Result: Demonstrates cell viability exceeding 75 % across all tested conditions.
体内研究
(In Vivo)

MAO-B-IN-49 (10 mg/kg，30 mg/kg，腹腔注射，每日一次，持续 7 天) 可显著改善帕金森病模型小鼠中 MPTP 诱导的运动功能障碍 (包括运动活动、协调性和肌肉力量)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A Parkinson's disease model was induced in male C57BL/6J mice (2 months old, weighing 20±2 g) by injection of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)[1].
Dosage: 10 mg/kg, 30 mg/kg
Administration: I.p., 30 mins before MPTP, once daily for 7 days
Result: Led to a near-normal restoration of movement patterns, indicating a significant improvement in motor function.
Significantly improved the movement disorder in mice.
Effectively relieved forelimb muscle weakness in mice.
分子量

362.37

Formula

C19H20F2N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAO-B-IN-49 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-493098883-91-8Monoamine OxidaseReactive Oxygen Species (ROS)MAOIsoform selectivityStructure activity relationshiphMAO-BParkinson’s diseasePDInhibitorinhibitorinhibit

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