2. MAPK/ERK Pathway
  3. MAP4K
  4. MAP4K4-IN-7

MAP4K4-IN-7 (Compound 8) 是一种 MAP4K4 抑制剂。MAP4K4-IN-7 对 TNIK、MAP4K4 和 MINK1 表现出中等抑制活性，其 pIC50 值分别为 6.8、6.8 和 6.7。MAP4K4-IN-7 可用于癌症和神经系统疾病的研究，如精神分裂症。

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MAP4K4-IN-7

MAP4K4-IN-7 Chemical Structure

CAS No. : 1499162-60-5

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MAP4K4-IN-7 相关抗体

Top Publications Citing Use of Products

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MAP4K4-IN-7 (Compound 8) is a MAP4K4 inhibitor. MAP4K4-IN-7 shows moderate inhibitory activity against TNIK, MAP4K4, and MINK1 with pIC50 values of 6.8, 6.8, and 6.7 respectively. MAP4K4-IN-7 can be used for the researches of cancer and neurological disease, such as schizophrenia[1].

IC50 & Target[1]

MAP4K4

6.8 (pIC50)

TNIK

6.8 (pIC50)

MINK1/MAP4K6

6.7 (pIC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Sf21 IC50
150 nM
Compound: 8
Inhibition of human 6His-TEV-Avi-MINK1(1 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 75 to 90 mins by ADP-Glo Reagent based method
Inhibition of human 6His-TEV-Avi-MINK1(1 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 75 to 90 mins by ADP-Glo Reagent based method
[PMID: 31153805]
Sf21 IC50
150 nM
Compound: 8
Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 75 to 90 mins by ADP-Glo Reagent based method
Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 75 to 90 mins by ADP-Glo Reagent based method
[PMID: 31153805]
Sf21 IC50
150 nM
Compound: 8
Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 75 to 90 mins by ADP-Glo Reagent based method
Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followed by substrate addition and measured after 75 to 90 mins by ADP-Glo Reagent based method
[PMID: 31153805]
分子量

241.22

Formula

C12H8FN5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MAP4K4-IN-7 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAP4K4-IN-71499162-60-5MAP4KMAPK Kinase Kinase KinaseInhibitorinhibitorinhibit

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