2. Academic Validation
  3. Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides

Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides

  • J Med Chem. 1991 Aug;34(8):2361-6. doi: 10.1021/jm00112a007.
J A Secrist 3rd 1,  K N Tiwari,  J M Riordan,  J A Montgomery
Affiliations

Affiliation

  • 1 Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
PMID: 1652015 DOI: 10.1021/jm00112a007
Abstract

2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in Cell Culture.

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