2. Academic Validation
  3. Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

  • Bioorg Med Chem Lett. 2010 Feb 15;20(4):1436-9. doi: 10.1016/j.bmcl.2009.12.085.
John Lloyd 1,  Heather J Finlay,  Wayne Vacarro,  Tram Hyunh,  Alexander Kover,  Rao Bhandaru,  Lin Yan,  Karnail Atwal,  Mary Lee Conder,  Tonya Jenkins-West,  Hong Shi,  Christine Huang,  Danshi Li,  Huabin Sun,  Paul Levesque
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, USA. john.lloyd@bms.com
PMID: 20097068 DOI: 10.1016/j.bmcl.2009.12.085
Abstract

Design and synthesis of pyrazolodihydropyrimidines as KV1.5 blockers led to the discovery of 7d as a potent and selective antagonist. This compound showed atrial selective prolongation of effective refractory period in rabbits and was selected for clinical development.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z