2. Academic Validation
  3. Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

Copper-mediated three-component synthesis of 3-cyanoimidazo[1,2-a]pyridines

  • Chem Commun (Camb). 2015 Oct 28;51(84):15378-81. doi: 10.1039/c5cc05821j.
Qiaodong Wen 1,  Ping Lu,  Yanguang Wang
Affiliations

Affiliation

  • 1 Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China. pinglu@zju.edu.cn orgwyg@zju.edu.cn.
PMID: 26344490 DOI: 10.1039/c5cc05821j
Abstract

A copper-mediated three-component approach towards the synthesis of 3-cyanoimidazo[1,2-a]pyridines from 2-aminopyridines, acetophenones and benzyl cyanide was developed. This cascade reaction proceeds through a copper-mediated oxidative release of cyanide from benzyl cyanide, a copper-mediated Ortoleva-King reaction, and a copper-catalyzed cyanation.

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