2. Academic Validation
  3. Eukaryotic DNA polymerases

Eukaryotic DNA polymerases

  • Curr Opin Struct Biol. 2018 Dec:53:77-87. doi: 10.1016/j.sbi.2018.06.003.
Rinku Jain 1,  Aneel K Aggarwal 2,  Olga Rechkoblit 1
Affiliations

Affiliations

  • 1 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA.
  • 2 Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address: aneel.aggarwal@mssm.edu.
PMID: 30005324 DOI: 10.1016/j.sbi.2018.06.003
Abstract

The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS). We emphasize here recent findings that accelerate our understanding of the structure and mechanisms of these remarkable Enzymes. We also highlight growing evidence on the role of DNA polymerases in the origin of certain cancers, and paradoxically as emerging targets for Cancer therapy.

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