Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

Affiliations

• 1 Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
• 2 Takeda Development Center Americas, Inc., Cambridge, MA 02139, USA.
• 3 Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland.
• 4 University of Basel, 4003 Basel, Switzerland.
• 5 Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
• 6 Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
• 7 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
• 8 Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton CB10 1SA, UK.
• 9 Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
• 10 Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.
• 11 St. Vincent's Institute of Medical Research, Fitzroy, VIC 3065, Australia.
• 12 Medicines for Malaria Venture, P.O. Box 1826, 20, Route de Pré-Bois, 1215 Geneva 15, Switzerland.
• 13 Seofon Consulting, Natick, MA 01760, USA.
• # Contributed equally.