2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease Thrombin
  4. MD5

MD5 是一种具有选择性的 TMPRSS6 模拟肽抑制剂，其对重组人 TMPRSS6 蛋白的 IC50 为 22 nM，Ki 为 3.4 nM。MD5 对 Matriptase 的抑制效力显著降低，IC50 为 352 nM，Ki 为 99.2 nM。MD5 具有良好的靶点特异性，仅对凝血酶 (Thrombin) 具有微弱的抑制，Ki 为 120 nM。MD5 展现了良好的初步成药性，可用于研究铁过载疾病 (如遗传性血色素沉着症、β-地中海贫血)。

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Custom Peptide Synthesis

MD5

MD5 Chemical Structure

CAS No. : 3051556-89-6

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MD5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MD5 is a selective TMPRSS6 mimetic peptide inhibitor with an IC50 for recombinant human TMPRSS6 protein of 22 nM and a Ki of 3.4 nM. MD5 exhibits the significantly reduced inhibitory effect on Matriptase, with an IC50 of 352 nM and a Ki of 99.2 nM. MD5 exhibits good target specificity and only has a weak inhibitory effect on thrombin (Thrombin), with Ki of 120 nM. MD5 demonstrates good initial drugability and can be used for the study of iron overload diseases (such as hereditary hemochromatosis, β-thalassemia)[1].
分子量

716.92

Formula

C36H44N8O4S2
CAS 号
Sequence

Phe{H}-Ala{Thiazolyl}-{Chg}-Arg{Kbt}
Sequence Shortening

Phe{H}-Ala{Thiazolyl}-{Chg}-Arg{Kbt}
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MD5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD53051556-89-6MD 5MD-5Ser/Thr ProteaseThrombinSerine proteasesSerine endopeptidasesThreonine proteasesTMPRSS6 inhibitorSubtype selectivityS2 subpocketPeptidomimeticKetobenzothiazole (Kbt)Cyclohexylglycine (Chg)Rational drug designIron overloadHepcidin modulationInhibitorinhibitorinhibit

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