2. Epigenetics Apoptosis
  3. SF3B1 Bcl-2 Family Apoptosis
  4. Meayamycin B

Meayamycin B ((+)-Meayamycin B) 是一种强效的 SF3B1 抑制剂。Meayamycin B 在前体 mRNA 剪接水平上上调促凋亡蛋白 Mcl-1S 的表达，并下调 Mcl-1L 的表达。Meayamycin B 不调节 Bcl-x 的选择性剪接。Meayamycin B 和 ABT-737 (HY-50907) 协同诱导细胞凋亡 (Apoptosis)。Meayamycin B 对非小细胞肺癌具有抗癌活性。

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Meayamycin B

Meayamycin B Chemical Structure

CAS No. : 1020210-12-1

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Meayamycin B 相关抗体

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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生物活性

Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer[1].

IC50 & Target[1]

Mcl-1

 

分子量

576.72

Formula

C31H48N2O8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Meayamycin B 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Meayamycin B1020210-12-1(+)-Meayamycin BSF3B1Bcl-2 FamilyApoptosisSplicing Factor 3b Subunit 1non-small cell lung cancerA549H1299Inhibitorinhibitorinhibit

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