2. Neuronal Signaling
  3. α-synuclein
  4. MEDI-1341

MEDI-1341 (TAK-341) 是一种可透过血脑屏障的抗 α-syn 单克隆抗体。MEDI-1341 可结合单体及聚集态 α-syn 的 C 端表位，穿透血脑屏障，降低脑脊液 (CSF) 和脑间质液中游离的细胞外 α-syn 水平，抑制 α-syn 预制原纤维的细胞间传递。MEDI-1341 可用于帕金森病的研究 [1] [2]。

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MEDI-1341

MEDI-1341 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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MEDI-1341 相关抗体

Top Publications Citing Use of Products

查看 α-synuclein 亚型特异性产品:

查看所有亚型
α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MEDI-1341 (TAK-341) is a blood-brain barrier-penetrant anti-α-synuclein monoclonal antibody. MEDI-1341 binds to the C-terminal epitope of both monomeric and aggregated forms of α-synuclein, penetrates the blood-brain barrier, reduces levels of free extracellular α-synuclein in cerebrospinal fluid (CSF) and brain interstitial fluid, and inhibits the cell-to-cell transmission of preformed α-synuclein fibrils. MEDI-1341 is applicable for research on Parkinson’s disease [1] [2].

反应种属

Human
IC50 & Target

CSF1R/M-CSFR/CD115
体外研究
(In Vitro)

MEDI1341 靶向单体和聚集形式的 α-突触核蛋白的 C 端表位[1]。
MEDI1341 已被证明可以阻止细胞培养物中人类 α-syn 预成型原纤维 (PFF) 的细胞间传播[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MEDI-1341 相关抗体:
体内研究
(In Vivo)

MEDI1341 (静脉注射) 被证实能够渗透到动物脑中，有效降低脑脊液和脑组织间液 (ISF) 中游离的细胞外 α-syn 水平[1]。
MEDI1341 可阻止小鼠模型中人类 α-突触核蛋白预形成原纤维 (PFF) 的细胞间传播[1]。
MEDI-1341 (100 mg/kg；静脉注射) 进入大鼠脑脊液，2-24 小时后游离 α-突触核蛋白减少 81%，脑组织间液中 α-突触核蛋白减少 75%[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

1436  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MEDI-1341 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MEDI-1341TAK-341MEDI1341MEDI 1341TAK341TAK 341α-synucleinα-Synparkinson’s diseaseCSFα-synPDcentral nervous systemblood-brain barrieraxonsmonomericalpha-synucleinC-terminal epitopebrain interstitial fluidcell-to-cell transmissionpreformed fibrilsmouse modelsaggregatedInhibitorinhibitorinhibit

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MEDI-1341
目录号：
HY-P991948
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