2. Others Immunology/Inflammation Apoptosis Metabolic Enzyme/Protease NF-κB Neuronal Signaling
  3. Insecticide SOD Glutathione Peroxidase Reactive Oxygen Species (ROS) Cholinesterase (ChE)
  4. Methiocarb

Methiocarb (Mercaptodimethur) 是一种具有口服活性的氨基甲酸酯类杀虫剂。Methiocarb 对洋葱表现出剂量依赖性毒性作用。Methiocarb 除了抑制乙酰胆碱酯酶 (Acetylcholinesterase) 引发胆碱能兴奋外，还可通过产生 ROS 诱导肝、肾、脑、睾丸组织发生脂质过氧化，改变还原型谷胱甘肽水平。Methiocarb 可用于农业害虫防治及哺乳动物氧化应激相关细胞损伤的研究。

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Methiocarb

Methiocarb Chemical Structure

CAS No. : 2032-65-7

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Other Forms of Methiocarb:

Methiocarb 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Methiocarb (Mercaptodimethur) is an orally active carbamate insecticide. Methiocarb exerts dose-dependent toxic effects on onions. In addition to inhibiting acetylcholinesterase to induce cholinergic excitation, Methiocarb can induce lipid peroxidation in liver, kidney, brain and testicular tissues and alter reduced glutathione levels by generating ROS. Methiocarb can be used for agricultural pest control and research on oxidative stress-related cellular damage in mammals[1][2].

体外研究
(In Vitro)

Methiocarb (2.5-7.5 mg/L；72 小时) 对Allium cepa L. 鳞茎具有剂量依赖性毒性作用，包括降低生根率、根长和增重率，增加微核率、染色体损伤程度和 MDA 水平，降低有丝分裂指数，以及提高 SOD 和 CAT 活性，其中 7.5 mg/L 浓度下的作用最强[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methiocarb 相关抗体:
体内研究
(In Vivo)

Methiocarb (2-25 mg/kg; i.g.; once/daily; 1-28 days) 会诱导大鼠肝脏、肾脏、大脑和睾丸发生脂质过氧化反应，并扰乱其谷胱甘肽水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar Albino (male, 12-13 weeks old, 160 ± 20 g)[2]
Dosage: 25 mg/kg (1-day treatment); 10 mg/kg (5-day treatment); 2 mg/kg (28-day treatment)
Administration: i.g.; once (1-day); daily (5-day, 28-day)
Result: Increased LPO in the liver, kidney, brain and testis after 1, 5 and 28 days treatment, with the most significant increase in the brain.
Significantly elevated GSH levels in all the above tissues after 1 day of treatment but significantly decreased after 5 and 28 days of treatment, and the decrease in GSH levels in the kidney, brain and testis was more pronounced than that in the liver.
分子量

225.31

Formula

C11H15NO2S
CAS 号
中文名称

甲硫威
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Methiocarb 相关分类

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Keywords:

Methiocarb2032-65-7Mercaptodimethur甲硫威InsecticideSODGlutathione PeroxidaseReactive Oxygen Species (ROS)Cholinesterase (ChE)Superoxide Dismutaselipid peroxidationmale Wistar ratsInhibitorinhibitorinhibit

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