2. Epigenetics Apoptosis
  3. METTL3 c-Myc Bcl-2 Family
  4. METTL3-IN-11

METTL3-IN-11 是一种优异的选择性 METTL3 抑制剂 (IC50 = 45.31 nM)。与 DNMT1、EZH1、MLL1 和 PRMT1 相比，METTL3-IN-11 对 METTL3 表现出较高的选择性。METTL3-IN-11 降低了 MOLM-13 和 SKOV3 细胞中总 RNA 的 m6A 水平，诱导细胞凋亡 (apoptosis)，并抑制细胞迁移。METTL3-IN-11 可以降低 m6A 下游靶基因 (c-MYC 和 BCL2) 的表达。METTL3-IN-11 可用于卵巢癌和急性髓系白血病的研究。

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METTL3-IN-11

METTL3-IN-11 Chemical Structure

CAS No. : 3069369-05-4

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METTL3-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

METTL3-IN-11 is an excellent, selective METTL3 inhibitor (IC50 = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia[1].

IC50 & Target

Bcl-2

 

体外研究
(In Vitro)

METTL3-IN-11 (Compound 30t) 在 SKOV3 (IC50 = 6.42 μM) 和 MOLM-13 (IC50 = 12.34 μM) 细胞中均表现出良好的抗增殖活性，同时在 LO2 和 HK2 细胞中显示出较低的毒性，HK2 细胞在 25 μM 和 50 μM 浓度下的存活率明显高于阳性对照 STM2457[1]。
METTL3-IN-11 (5-15 μM) 以剂量依赖的方式降低 SKOV3 和 MOLM-13 细胞中总 RNA 的 m6A 水平。
METTL3-IN-11 (10-25 μM，48 h) 显著抑制 SKOV3 细胞的迁移能力并诱导细胞凋亡。
METTL3-IN-11 (10-25 μM，48 小时) 不影响 METTL3 蛋白的表达水平，但以剂量依赖的方式下调 SKOV3 和 MOLM-13 细胞中 m6A 下游靶基因 (如 c-MYC 和 BCL2) 的蛋白表达。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

METTL3-IN-11 相关抗体:

Cell Migration Assay [1]

Cell Line: SKOV3 cells
Concentration: 10 μM, 25 μM
Incubation Time: 48 h
Result: Significantly inhibits the migratory capability of SKOV3 cells.

Western Blot Analysis[1]

Cell Line: SKOV3 cells, MOLM-13 cells
Concentration: 10 μM, 25 μM
Incubation Time: 48 h
Result: Did not affect the expression level of METTL3 protein.
Downregulated the protein expression of downstream target genes of m6A (such as c-MYC and BCL2).
体内研究
(In Vivo)

METTL3-IN-11 (Compound 30t) (50 mg/kg，腹腔注射，每日一次，持续 2 周) 可显著抑制 SKOV3 荷瘤小鼠的肿瘤生长，并在实验期间保持体重稳定，且未观察到明显的毒性反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SKOV3 cells were subcutaneously inoculated into the right flank of female BALB/c mice (4–5 weeks old)[1].
Dosage: 50 mg/kg
Administration: I.p., once daily for 2 weeks
Result: Significantly inhibited tumor growth.
No significant difference was observed in the body weight.
分子量

472.54

Formula

C26H28N6O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

METTL3-IN-11 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

METTL3-IN-113069369-05-4METTL3c-MycBcl-2 FamilyMethyltransferase-like 3MycAcute myeloid leukemiaImidazo[1,2-a]pyridineMETTL3 inhibitorOvarian carcinomaInhibitorinhibitorinhibit

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