2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. mGluR Steroid Sulfatase
  4. mGluR1 activator-1

mGluR1 activator-1 是一种稳定的、可透过血脑屏障的维生素 K (HY-B2172) 类似物和 mGluR1 激活剂。mGluR1 activator-1 能通过类固醇和外源性物质受体及视黄酸受体实现强转录激活。mGluR1 activator-1 能有效诱导小鼠神经祖细胞的神经分化。mGluR1 activator-1 可用于神经退行性疾病，如阿尔茨海默的研究。

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mGluR1 activator-1

mGluR1 activator-1 Chemical Structure

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mGluR1 activator-1 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

查看所有亚型
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

mGluR1 activator-1 is a stable Vitamin K (HY-B2172) analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s[1].

IC50 & Target[1]

mGluR1

 

体外研究
(In Vitro)

mGluR1 activator-1 (Compound 7) (1-10 μM, 48 h) 在神经干细胞中通过 SXR 和 RAR 调节了转录活性[1]。
mGluR1 activator-1 (1 μM, 48 h) 显著增加了 Map2 阳性信号，表明其能有效诱导神经祖细胞向神经元分化[1]。
mGluR1 activator-1 (1-10 μM, 24 h) 在 MG63 细胞显示出浓度依赖性的细胞摄取增加，且能被细胞转化为生物活性形式 Menaquinone-4 (MK-4) (HY-B2156)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

mGluR1 activator-1 相关抗体:

RT-PCR[1]

Cell Line: Neural progenitor cellsneural progenitor cells
Concentration: 1 μM
Incubation Time: 48 h
Result: Observed a significant increase in Map2 mRNA expression.
体内研究
(In Vivo)

mGluR1 activator-1 (Compound 7) (10 μmol/mL, p.o., 单次给药) 在 C57BL6J 小鼠体内比 MK-4 更早进入脑，并在给药后 24 小时转化为 MK-4[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

418.52

Formula

C27H30O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

mGluR1 activator-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mGluR1 activator-1mGluRSteroid SulfataseMetabotropic glutamate receptorsVitamin KRetinoic acidNeuronal differentiationNuclear receptorPharmacokineticsBiological metabolismInhibitorinhibitorinhibit

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