2. GPCR/G Protein
  3. Adenosine Receptor
  4. MIPS3526

MIPS3526 是一种强效且选择性的 A2B 腺苷受体 (A2BR) 激动剂，其 pEC50 值为 10.17 (EC50 值为 58 pM)。MIPS3526 对 A1R、A2AR 和 A3R 具有高度受体亚型选择性。MIPS3526 可减轻血管紧张素 II 在心肌细胞和成纤维细胞中的刺激作用。MIPS3526 可用于研究心血管疾病，包括以心脏重塑为主要驱动因素的心力衰竭。

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MIPS3526

MIPS3526 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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MIPS3526 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MIPS3526 is a potent and selective A2B adenosine receptor (A2BR) agonist with a pEC50 of 10.17 (EC50 of 58 pM). MIPS3526 shows highly receptor subtype selective versus the A1R, A2AR, and A3R. MIPS3526 ameliorates angiotensin II stimulating effects in both cardiac myocytes and fibroblasts. MIPS3526 can be used for the study of cardiovascular disease including heart failure where cardiac remodeling is a major driver[1].

IC50 & Target[1]

A2BR

10.24 (pEC50)

A2BR

58 pM (EC50)

A1AR

7.08 (pEC50)

A2AR

6.72 (pEC50)

A3R

5.48 (pEC50)

体外研究
(In Vitro)

MIPS3526 (compound 7; 1-10 μM) 可改善血管紧张素 II 诱导的新生大鼠心肌细胞 (NCM) 肥大[1]。
MIPS3526 (1-10 μM) 可减弱 TGFβ 刺激的心脏成纤维细胞胶原合成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MIPS3526 相关抗体:
分子量

880.94

Formula

C44H43F3N10O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MIPS3526 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MIPS3526MIPS 3526MIPS-3526Adenosine ReceptorP1 receptorA2BR cardiovascular disease cardiac myocytes fibroblastsInhibitorinhibitorinhibit

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产品名称：
MIPS3526
目录号：
HY-179277
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