2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Mitochondrial-targeted peptide BP29

Mitochondrial-targeted peptide BP29 是一种与一种线粒体归巢的 SS-肽相连的线粒体靶向的铁螯合剂。Mitochondrial-targeted peptide BP29 可保护人原代皮肤成纤维细胞，免受紫外线 A 诱导的线粒体膜氧化损伤、ATP 耗竭及坏死性细胞死亡。Mitochondrial-targeted peptide BP29 能够防止过氧化氢诱导的健康及弗里德赖希共济失调皮肤成纤维细胞氧化应激及细胞毒性。Mitochondrial-targeted peptide BP29 可用于弗里德赖希共济失调的研究。

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Custom Peptide Synthesis

Mitochondrial-targeted peptide BP29

Mitochondrial-targeted peptide BP29 Chemical Structure

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Mitochondrial-targeted peptide BP29 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mitochondrial-targeted peptide BP29 is a mitochondria-targeted iron chelator linked to a mitochondria-homing SS-peptide. Mitochondrial-targeted peptide BP29 protects human primary skin fibroblasts against ultraviolet A-induced oxidative damage to mitochondrial membranes, ATP depletion, and necrotic cell death. Mitochondrial-targeted peptide BP29 prevents hydrogen peroxide-induced oxidative stress and cytotoxicity in both healthy and Friedreich's ataxia skin fibroblasts. Mitochondrial-targeted peptide BP29 can be used for the research of Friedreich's ataxia[1].

体外研究
(In Vitro)

Mitochondrial-targeted peptide BP29 (50 μM； 预处理过夜) 可保护 FEK4 人原代皮肤成纤维细胞免受 ultraviolet A (UVA) 诱导的氧化损伤和坏死性细胞死亡[1]。
Mitochondrial-targeted peptide BP29 (50 μM；预处理过夜) 可保护 FRDA 皮肤成纤维细胞免受 UVA 诱导的细胞死亡 [1]。
Mitochondrial-targeted peptide BP29 (50 μM；预处理过夜) 可保护 FRDA 和健康皮肤成纤维细胞免受 H2O2 诱导的细胞毒性损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mitochondrial-targeted peptide BP29 相关抗体:
分子量

1199.31

Formula

C57H78N14O15
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mitochondrial-targeted peptide BP29 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitochondrial-targeted peptide BP29Mitochondrial MetabolismmitochondriaFRDAFriedreich's ataxiaUVAxidative damagenecrotic cell deathoxidative stressFEK4ATPInhibitorinhibitorinhibit

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