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Mitoflaxone  (Synonyms: Flavoneacetic acid)

目录号: HY-119340
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Mitoflaxone (flavoneacetic acid) 是一种具有血管靶向特性的合成黄酮类化合物。 Mitoflaxone 通过一种超氧化物依赖性的机制对内皮细胞产生抗增殖作用，这种作用会导致肿瘤血管的通透性发生变化，从而发挥抗肿瘤作用。

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Mitoflaxone

Mitoflaxone Chemical Structure

CAS No. : 87626-55-9

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Mitoflaxone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mitoflaxone (flavoneacetic acid) is a synthetic flavonoid compound with vascular targeting properties. Mitoflaxone exerts anti-proliferative effects on endothelial cells through a superoxide-dependent mechanism, this effect leads to changes in the permeability of tumor blood vessels, thereby exerting anti-tumor effects[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
2008 IC50
421.3 μM
Compound: FAA (Flavone -8-acetic acid)
Direct cytotoxicity against the selected tumor cell line 2008 was determined especially on ovarian adenocarcinoma derived cells
Direct cytotoxicity against the selected tumor cell line 2008 was determined especially on ovarian adenocarcinoma derived cells
[PMID: 12904070]
A549 IC50
341.5 μM
Compound: 2, FAA
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
[PMID: 24518295]
C13 IC50
233.3 μM
Compound: FAA (Flavone -8-acetic acid)
Direct cytotoxicity against the selected tumor cell line c13* was determined especially on ovarian adenocarcinoma derived cells
Direct cytotoxicity against the selected tumor cell line c13* was determined especially on ovarian adenocarcinoma derived cells
[PMID: 12904070]
DLD-1 IC50
> 500 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
In vitro concentration required to inhibit DLD1 cells
In vitro concentration required to inhibit DLD1 cells
10.1016/0960-894X(94)85031-3
HCT-8 IC50
245 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
In vitro concentration required to inhibit HCT18 cells
In vitro concentration required to inhibit HCT18 cells
10.1016/0960-894X(94)85031-3
HT-29 IC50
2449.5 μM
Compound: 2, FAA
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
[PMID: 24518295]
HT-29 IC50
390 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
In vitro concentration required to inhibit HT-29 cells
In vitro concentration required to inhibit HT-29 cells
10.1016/0960-894X(94)85031-3
K562 IC50
310 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
In vitro concentration required to inhibit K562 cells
In vitro concentration required to inhibit K562 cells
10.1016/0960-894X(94)85031-3
LoVo IC50
378.3 μM
Compound: FAA (Flavone -8-acetic acid)
In vitro cytotoxicity against the selected tumor cell line LoVoR arising from human colon adenocarcinoma was determined
In vitro cytotoxicity against the selected tumor cell line LoVoR arising from human colon adenocarcinoma was determined
[PMID: 12904070]
LoVo IC50
563.9 μM
Compound: FAA (Flavone -8-acetic acid)
In vitro cytotoxicity against the selected tumor cell line LoVoS arising from human colon adenocarcinoma was determined
In vitro cytotoxicity against the selected tumor cell line LoVoS arising from human colon adenocarcinoma was determined
[PMID: 12904070]
MAC15A IC50
150 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
In vitro concentration required to inhibit MAC 15 A cells
In vitro concentration required to inhibit MAC 15 A cells
10.1016/0960-894X(94)85031-3
MAC16 IC50
180 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
In vitro concentration required to inhibit MAC 16 cells
In vitro concentration required to inhibit MAC 16 cells
10.1016/0960-894X(94)85031-3
MAC26 IC50
208 μg/mL
Compound: 1 (FAA, NSC-347512 LM975)
In vitro concentration required to inhibit MAC 26 cells
In vitro concentration required to inhibit MAC 26 cells
10.1016/0960-894X(94)85031-3
分子量

280.27

Formula

C17H12O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mitoflaxone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mitoflaxone87626-55-9Flavoneacetic acidOthersflavoneacetic acidantineoplastic drugflavonoidanticancer agentvascular targetingimmune modulationclinical developmentstructure-activity relationshipcombination therapyInhibitorinhibitorinhibit

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目录号：
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