2. Anti-infection Metabolic Enzyme/Protease
  3. HBV HCV Protease
  4. MK-1220

MK-1220 是一种共价可逆的丙型肝炎病毒 (HCV) NS3/4A 蛋白酶 (NS3/4A protease) 抑制剂，其 Ki 为 0.02 nM。MK-1220 在模拟病毒复制的细胞模型中的 EC50 分别为 4 (含 10% 胎牛血清) 和 11 nM (50% 正常人血清)。MK-1220 可用于研究慢性丙型肝炎病毒感染。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

MK-1220

MK-1220 Chemical Structure

CAS No. : 924270-31-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MK-1220 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a Ki of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC50s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh-7 IC50
11 nM
Compound: 15j, MK-1220
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% normal human serum
[PMID: 24900304]
Huh-7 IC50
11 nM
Compound: 2
Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS
Antiviral activity against Hepatitis C virus (isolate Con1) genotype 1b infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 50% NHS
[PMID: 24900473]
Huh-7 IC50
4 nM
Compound: 15j, MK-1220
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
Antiviral activity against HCV1b con1 infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
[PMID: 24900304]
Huh-7 IC50
5 nM
Compound: 15j, MK-1220
Antiviral activity against HCV2a infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
Antiviral activity against HCV2a infected in human HuH7 cells assessed as inhibition of viral replication after 24 hrs in presence of 10% fetal bovine serum
[PMID: 24900304]
分子量

779.94

Formula

C40H53N5O9S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK-1220 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-1220924270-31-5MK1220MK 1220HBVHCV ProteaseHepatitis B virusHCV NS3/4A proteasemacrocyclic inhibitorpharmacokineticsliver exposureInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MK-1220
目录号：
HY-14404
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z