2. Anti-infection Metabolic Enzyme/Protease
  3. HCV Protease HCV
  4. MK-2748

MK-2748 是一种丙型肝炎病毒 (HCV) NS3/4a 蛋白酶抑制剂。MK-2748 表现出广谱且强效的抗病毒活性，对 gt1a-gt6 均具纳摩尔级活性 (IC₅₀ < 0.115 nM)，仅对 gt3a 稍弱 (1.212 nM)，且对耐药突变株如 gt1b R155K (IC₅₀ = 0.032 nM) 和 D168Y (IC₅₀ = 0.057 nM) 保持高效抑制。MK-2748 可用于 HCV 感染的研究。

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MK-2748

MK-2748 Chemical Structure

CAS No. : 1193902-95-2

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MK-2748 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor. MK-2748 exhibits broad-spectrum and potent antiviral activity, with nanomolar-level activity against all genotypes (gt1a-gt6) (IC₅₀ < 0.115 nM), showing only slightly weaker activity against gt3a (1.212 nM), and maintaining high inhibitory activity against drug-resistant mutant strains such as gt1b R155K (IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM). MK-2748 can be used in the research of HCV infection[1].

分子量

836.99

Formula

C42H56N6O10S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MK-2748 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-27481193902-95-2MK2748MK 2748HCV ProteaseHCVHepatitis C virusMK-6325antiviral agentshepatitis?CmacrocyclesInhibitorinhibitorinhibit

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目录号：
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