2. Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. MMP STAT Apoptosis
  4. MMP-2/9-IN-2

MMP-2/9-IN-2 (Compound 6k) 是一种 MMP-2 和 MMP-9 抑制剂，其 IC50 分别为 29.27 和 24.87 μM。MMP-2/9-IN-2 对多种人源肝癌细胞系具有良好的选择性毒性。MMP-2/9-IN-2 诱导细胞周期阻滞和细胞凋亡 (apoptosis)、显著抑制细胞的迁移和侵袭。MMP-2/9-IN-2 抑制 STAT3 信号通路的磷酸化。MMP-2/9-IN-2 在 HepG2 肝癌细胞裸鼠移植瘤模型表现出强抗肿瘤活性。

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MMP-2/9-IN-2

MMP-2/9-IN-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

MMP-2/9-IN-2 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

生物活性

MMP-2/9-IN-2 (Compound 6k) is a MMP-2 and MMP-9 inhibitor, with IC50 values of 29.27 and 24.87 μM respectively. MMP-2/9-IN-2 exhibits good selective toxicity against multiple human hepatoma cell lines. MMP-2/9-IN-2 induces cell cycle arrest and apoptosis, significantly inhibits cell migration and invasion. MMP-2/9-IN-2 inhibits the phosphorylation of the STAT3 signaling pathway. MMP-2/9-IN-2 shows strong anti-tumor activity in a nude mouse xenograft model of HepG2 liver cancer cells[1].

IC50 & Target[1]

MMP-2

29.27 μM (IC50)

MMP-9

24.87 μM (IC50)

STAT3

 

分子量

413.51

Formula

C23H31N3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

MMP-2/9-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-2/9-IN-2MMPSTATApoptosisMatrix metalloproteinasesResveratrol derivativeUrea backbone6kHepatocellular carcinomaSTAT3 signalingMetastasis inhibitionApoptosis inductionInhibitorinhibitorinhibit

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MMP-2/9-IN-2
目录号：
HY-180117
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