2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. MMP Apoptosis Reactive Oxygen Species (ROS)
  4. MMP-9-IN-12

MMP-9-IN-12 是一种基质金属蛋白酶-9 (MMP-9) 抑制剂，其 IC50 值为 6.57 μM。MMP-9-IN-12 对 HCT-116 细胞的 IC50 值为1.54 μM。MMP-9-IN-12 可诱导细胞凋亡 (apoptosis)、活性氧 (ROS) 生成及线粒体去极化。MMP-9-IN-12 能抑制细胞迁移并破坏细胞周期进程。MMP-9-IN-12 可用于结直肠癌 (CRC) 的研究。

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MMP-9-IN-12

MMP-9-IN-12 Chemical Structure

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MMP-9-IN-12 相关抗体

Top Publications Citing Use of Products

查看 MMP 亚型特异性产品:

查看所有亚型
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMP-9-IN-12 is a matrix metalloproteinase-9 (MMP-9) inhibitor with an IC50 of 6.57 μM. MMP-9-IN-12 shows an IC50 value of 1.54 μM for HCT-116 cells. MMP-9-IN-12 induces cell apoptosis, ROS production and mitochondrial depolarization. MMP-9-IN-12 inhibits cells migration and disrupts cell cycle progression. MMP-9-IN-12 can be used for the research of colorectal cancer (CRC)[1].

IC50 & Target[1]

MMP-9

6.57 μM (IC50)

体外研究
(In Vitro)

MMP-9-IN-12 (compound 10 g) 在 HCT-116 癌细胞系中的 IC50 值为 1.54 μM，在其余癌细胞系中具有中等活性，IC50 值的范围为 14.41-24.35 μM[1]。
MMP-9-IN-12 (0.77-3.08 μM, 48 h) 可诱导 HCT-116 细胞凋亡、活性氧 (ROS) 产生和线粒体去极化[1]。
MMP-9-IN-12 (0.77-3.08 μM, 48 h) 以剂量依赖性方式减少 HCT-116 细胞的集落形成数量[1]。
MMP-9-IN-12 (0.77-3.08 μM, 48 h) 减少 HCT-116 细胞中 S 期和 G2 期的细胞数量，同时增加 G0/G1 期的细胞数量[1]。
MMP-9-IN-12 (0.77-3.08 μM, 48 h) 降低 HCT-116 细胞中 MMP9 的表达[1]。
MMP-9-IN-12 (0.77-3.08 μM, 48 h) 抑制 HCT-116 细胞的迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MMP-9-IN-12 相关抗体:

Apoptosis Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.77, 1.54 and 3.08 μM
Incubation Time: 48 h
Result: Increased apoptosis in a dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.77, 1.54 and 3.08 μM
Incubation Time: 48 h
Result: Reduced cell population in the S and G2 phases while increasing in the G0/G1 phase.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.77, 1.54 and 3.08 μM
Incubation Time: 48 h
Result: Reduced MMP9 expression.
分子量

517.96

Formula

C28H24ClN3O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MMP-9-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMP-9-IN-12MMPApoptosisReactive Oxygen Species (ROS)Matrix metalloproteinasesMatrix metalloproteinaseHCT-116ROSCRCInhibitorinhibitorinhibit

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