2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis DNA/RNA Synthesis
  4. Morindone

Morindone 是一种被发现存在于巴戟天 (Morinda citrifolia L) 中的蒽醌类化合物。Morindone 能够抑制癌细胞增殖、诱导凋亡 (apoptosis) 并导致 G1 期阻滞。Morindone 可以抑制DNA 聚合酶 (DNA polymerase) 的活性，并下调突变的 TP53 和 KRAS 基因表达。Morindone 可用于癌症研究，如结肠癌。

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Morindone

Morindone Chemical Structure

CAS No. : 478-29-5

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Morindone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer[1][2].

体外研究
(In Vitro)

Morindone (0.39-50 μM, 24-72 h) 可抑制 KRAS 突变型 HCT116 和 TP53 突变型 HT29 结直肠癌细胞的增殖[1]。
Morindone (10.7-19.2 μM, 72 h) 可诱导 HCT116 和 HT29 细胞凋亡[1]。
Morindone (10.7-19.2 μM, 24-72 h) 可诱导 HCT116 和 HT29 细胞发生 G1 期阻滞[1]。
Morindone (10.7-19.2 μM, 72 h) 可下调 HCT116 细胞中突变的 KRAS、BRAF 和突变的 PIK3CA，下调 HT29 细胞中突变的 TP53 和 BAX，同时上调 HT29 细胞中的 p21[1]。
Morindone (28.1-35.9 μM, 60 mins) 可抑制动物 A 家族、B 家族和 Y 家族 DNA 聚合酶的活性，其 IC50 值为 28.1-35.9 μM[2]。
Morindone (24 h) 可抑制人结肠癌 HCT116 细胞的增殖，其 LD50 值为 32.2 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Morindone 相关抗体:

Cell Proliferation Assay[1]

Cell Line: KRAS-mutant HCT116 and TP53-mutant HT29 colorectal cancer cells
Concentration: 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 and 50 μM
Incubation Time: 24, 48 and 72 h
Result: Showed 3.06% proliferation inhibition in HCT116 cells at 3.12 μM for 24 h and complete proliferation inhibition at 50 μM for 72 h.
Exhibited 20.5% inhibition at 0.78 μM for 24 h and over 90% inhibition at 12.5-50 μM for 72 h in HT29 cells.

Western Blot Analysis[1]

Cell Line: HCT116 and HT29 cells
Concentration: 10.7 μM for HCT116, 19.2 μM for HT29
Incubation Time: 72 h
Result: Downregulated mutated KRAS, BRAF, and mutated PIK3CA in HCT116 cells.
Downregulated mutated TP53 and BAX, while upregulates p21 in HT29 cells.
分子量

270.24

Formula

C15H10O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Morindone 相关分类

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Keywords:

Morindone478-29-5ApoptosisDNA/RNA SynthesisMorinda citrifolia LAnthraquinoneDNA polymeraseTP53KRASColon cancerInhibitorinhibitorinhibit

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