2. MAPK/ERK Pathway PROTAC
  3. MEK PROTACs
  4. MS910

MS910 是一种高效选择性 MEK1/2 PROTAC 降解剂。MS910 在多种癌细胞中表现出有效的 MEK1/2 降解能力和抗增殖活性，如 HT-29 (MEK1 DC50 = 118 nM，MEK2 DC50 = 55 nM)、SK-MEL-28 (MEK1 DC50 = 94 nM，MEK2 DC50 = 38 nM) 细胞。MS910 常用于癌症的研究。(粉色: MEK1/2 配体 (HY-10254); 蓝色: CRBN 配体 (HY-W087383); 黑色: 连接子 (HY-W022240))

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MS910

MS910 Chemical Structure

CAS No. : 2756323-28-9

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规格 是否有货
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Customer Review

MS910 相关抗体

Top Publications Citing Use of Products

查看 MEK 亚型特异性产品:

查看所有亚型
MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MS910 is an efficient and selective MEK1/2 PROTAC degrader. MS910 exhibits effective MEK1/2 degradation ability and anti proliferative activity in various cancer cells, such as HT-29 (MEK1 DC50 = 118 nM, MEK2 DC50 = 55 nM) and SK-MEL-28 (MEK1 DC50 = 94 nM, MEK2 DC50 = 38 nM) cells. MS910 is commonly used in cancer research. (Pink: MEK1/2 Ligand (HY-10254); Blue: CRBN Ligand (HY-W087383); Black: Linker (HY-W022240))[1]

IC50 & Target[1]

MEK1

 

MEK2

 

Cereblon

 

分子量

984.75

Formula

C41H48F3IN6O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MS910 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MS9102756323-28-9MS 910MS-910MEKPROTACsMitogen-activated protein kinase kinaseMAPKKMAP2KMEK1/2PROTACHT-29SK-MEL-28cancerInhibitorinhibitorinhibit

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