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  4. MS99-β-Gal

MS99-β-Gal (Gal-MS99) 是一种半乳糖修饰的 NPM-ALK PROTAC 降解剂。MS99-β-Gal 仅在衰老癌细胞中被 SA-β-半乳糖苷酶 (SA-β-gal) 和酯酶水解，释放出 MS99，特异性降解 NPM-ALK 融合蛋白。MS99-β-Gal 对衰老的 Karpas 299 细胞的 IC50 值为 454.8 nM，显著低于对正常 Karpas 299 细胞 (IC50 = 2.162 μM)。MS99-β-Gal 可用于癌症研究。
(粉色: Anaplastic lymphoma kinase (ALK) 和 Insulin Receptor 和 IGF-1R 配体 (HY-15656)；蓝色: Ligands for E3 Ligase 和 VHL 配体 (HY-112078)；黑色: 连接子)。

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MS99-β-Gal

MS99-β-Gal Chemical Structure

CAS No. : 3055593-63-7

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MS99-β-Gal 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

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生物活性

MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells (IC50 = 2.162 μM). MS99-β-Gal can be used for the research of cancer[1]. (Pink: Anaplastic lymphoma kinase (ALK) and Insulin Receptor and IGF-1R ligand (HY-15656); Blue: Ligands for E3 Ligase and VHL ligand (HY-112078); Black: linker).

分子量

1579.23

Formula

C78H96ClN9O20S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MS99-β-Gal 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

MS99-β-Gal3055593-63-7Gal-MS99PROTACsInhibitorinhibitorinhibit

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