2. PI3K/Akt/mTOR Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. mTOR Apoptosis Reactive Oxygen Species (ROS) STING
  4. MT-44

MT-44 是一种高选择性和强效的 mTOR 抑制剂，其 IC50 值为 49.4 nM。MT-44 能够抑制癌细胞的增殖、迁移和侵袭。MT-44 可以诱导细胞凋亡 (apoptosis) 和活性氧 (ROS) 的产生，并导致 G2/M 期阻滞。MT-44 能够激活 cGAS/STING 通路。MT-44 可用于癌症研究，如三阴性乳腺癌的研究。

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MT-44

MT-44 Chemical Structure

CAS No. : 2966790-70-3

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MT-44 相关抗体

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MT-44 is a highly selective and potent mTOR inhibitor with an IC50 of 49.4 nM. MT-44 can inhibit cancer cells proliferation, migration and invasion. MT-44 can induce cells apoptosis and ROS production and cause G2/M phase arrest. MT-44 can activate the cGAS/STING pathway. MT-44 can be used for the research of cancer, such as triple-negative breast cancer[1].

体外研究
(In Vitro)

MT-44 对 TNBC 细胞 MDA-MB-231 和 MDA-MB-468 具有强效抗增殖活性，IC50 分别为 66.5 nM 和 148.2 nM[1]。
MT-44 (0.25-1.0 μM, 12-48 h) 浓度依赖性抑制 MDA-MB-231 细胞迁移，并诱导细胞 G2/M 期阻滞[1]。
MT-44 (0.05-0.5 μM) 显著抑制 MDA-MB-231 细胞集落形成和侵袭[1]。
MT-44 (0.5-2.0 μM, 24 h) 浓度依赖性诱导 MDA-MB-231 细胞凋亡，促进细胞自噬并增加 ROS 积累[1]。
MT-44 (0.5-2.0 μM, 24 h) 下调 MDA-MB-231 细胞中 p-P70S6K、p-Akt、p-4EBP1 的磷酸化水平，并上调 cGAS/STING 通路磷酸化蛋白[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MT-44 相关抗体:

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.5, 1 and 2 μM
Incubation Time: 24 h
Result: Increased apoptotic cells.
Upregulated the expression of γ-H2AX and the ratio of BAX/BCL2.
体内研究
(In Vivo)

MT-44 (10-20 mg/kg，静脉注射，每 3 天一次，持续 15 天) 在雌性 BALB/c 裸鼠 MDA-MB-231 异种移植模型中，显著抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice with MDA-MB-231 xenografts[1]
Dosage: 10 and 20 mg/kg
Administration: Intravenously injection, once every 3 days for 15 days
Result: Showed tumor growth inhibition rates (TGI) of 38.64% and 72.73%.
Had obvious organ toxicity.
Downregulated phosphorylated proteins of the mTOR pathway in tumor tissues.
Activated the cGAS/STING pathway, increased NK cell infiltration, and reduced regulatory T cells and tumor-associated macrophages.
分子量

469.49

Formula

C26H23N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MT-44 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-442966790-70-3MT44MT 44mTORApoptosisReactive Oxygen Species (ROS)STINGMammalian target of RapamycinStimulator of Interferon GenesTMEM173MITAERISMPYSInhibitorinhibitorinhibit

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