2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel Cholinesterase (ChE)
  4. Multi-kinase-IN-10

Multi-kinase-IN-10 (Compound IIIk) 是一种多激酶抑制剂。Multi-kinase-IN-10 具有显著的钙通道阻断活性，其 IC50 为 26.67 μM。Multi-kinase-IN-10 是一种强效的双重胆碱酯酶抑制剂，对 hAChE 和 hBuChE 的 IC50 分别为 0.304 μM 和 1.033 μM。Multi-kinase-IN-10 具有抗氧化活性和神经保护活性，并表现出显著的抗遗忘活性。Multi-kinase-IN-10 可用于研究阿尔茨海默症。

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Multi-kinase-IN-10

Multi-kinase-IN-10 Chemical Structure

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Multi-kinase-IN-10 相关抗体

Top Publications Citing Use of Products

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase-IN-10 (Compound IIIk) is a multi-kinase inhibitor. Multi-kinase-IN-10 exhibits significant calcium channel blocking activity, with its IC50 being 26.67 μM. Multi-kinase-IN-10 is a potent dual cholinesterase inhibitor, with its IC50 values for hAChE and hBuChE being 0.304 μM and 1.033 μM respectively. Multi-kinase-IN-10 has antioxidant and neuroprotective activities, and shows significant anti-amnesia activity. Multi-kinase-IN-10 can be used for research on Alzheimer's disease[1].

IC50 & Target[1]

CaV1.1

26.67 μM (IC50)

hAChE

0.304 μM (IC50)

hBCHE

1.033 μM (IC50)

分子量

750.08

Formula

C36H38BrClN6O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-10Calcium ChannelCholinesterase (ChE)Ca2+ channelsCa channelsAlzheimer's diseaseMTDLmulticomponent reactionclick reactiongreen chemistryCholinesterase inhibitorsCalcium channel blockadeNeuroprotectionInhibitorinhibitorinhibit

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