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  4. Multi-target kinase-IN-6

Multi-target kinase-IN-6 是一种多靶点激酶抑制剂。Multi-target kinase-IN-6 能够抑制心脏 RyR2 通道和 NaV1.5 通道，但会刺激 SERCA2a 泵的活性。Multi-target kinase-IN-6 可用于心血管疾病的研究，如心力衰竭。

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Multi-target kinase-IN-6

Multi-target kinase-IN-6 Chemical Structure

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Multi-target kinase-IN-6 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Multi-target kinase-IN-6 is a Multiple target kinase inhibitor. Multi-target kinase-IN-6 can inhibit cardiac RyR2- and NaV1.5-channels but stimulate SERCA2a pump activity. Multi-target kinase-IN-6 can be used for the research of cardiovascular disease, such as heart failure[1].

体外研究
(In Vitro)

Multi-target kinase-IN-6 (Compound 12) (25 μM, 24 h) 可抑制 HEK-293 RyR2 R-CEPIA1er 细胞中 RyR2 介导的 Ca2+ 泄漏[1]。
Multi-target kinase-IN-6 (1.1 μM, 2 h) 可激活 HL-1 心肌细胞中的肌浆网 Ca2+-ATP 酶 (SERCA2a)[1]。
Multi-target kinase-IN-6 (2.3 nM, 10 mins) 能显著增强从成年小鼠心室分离的肌浆网微粒体囊泡中 SERCA2a 的 ATP 酶活性[1]。
Multi-target kinase-IN-6 (10 μM, 30 mins) 可抑制 CHO NaV1.5 Duo 细胞中 NaV1.5 介导的 Na+ 内流[1]。
Multi-target kinase-IN-6 (10 μM, 24 h) 对 HL-1 心肌细胞无显著细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Multi-target kinase-IN-6 相关抗体:
分子量

481.46

Formula

C26H36BN3O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-target kinase-IN-6 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Multi-target kinase-IN-6OthersRyR2NaV1.5SERCA2aheart failureHL-1Inhibitorinhibitorinhibit

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