2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. Raf c-Met/HGFR Pim EGFR VEGFR Apoptosis
  4. Multi-target kinase-IN-8

Multi-target kinase-IN-8 (3d) 是一种抗癌剂。Multi-target kinase-IN-8 对多种蛋白激酶 (B-Raf V600E (IC50 = 0.078 µg/mL)、c-Met (IC50 = 0.405 µg/mL)、Pim-1 (IC50 = 1.053 µg/mL)、EGFR WT (IC50 = 0.177 µg/mL)、VEGFR-2 (IC50 = 0.275 µg/mL)) 表现出抑制活性。Multi-target kinase-IN-8 能诱导细胞周期阻滞并促进早期和晚期凋亡 (apoptosis)。Multi-target kinase-IN-8 常用于癌症的研究。

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Multi-target kinase-IN-8

Multi-target kinase-IN-8 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Multi-target kinase-IN-8 相关抗体

Top Publications Citing Use of Products

查看 Raf 亚型特异性产品:

查看所有亚型
B-Raf C-Raf Raf

查看 Pim 亚型特异性产品:

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PIM1 PIM2 PIM3

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-target kinase-IN-8 (3d) is an anti-cancer agent. Multi-target kinase-IN-8 exhibits inhibitory activity against various protein kinases (B-Raf V600E (IC50 = 0.078 µg/mL), c-Met (IC50 = 0.405 µg/mL), Pim-1 (IC50 = 1.053 µg/mL), EGFR WT (IC50 = 0.177 µg/mL), VEGFR-2 (IC50 = 0.275 µg/mL)). Multi-target kinase-IN-8 can induce cell cycle arrest and promote early and late apoptosis. Multi-target kinase-IN-8 is commonly used in cancer research[1].

IC50 & Target[1]

VEGFR-2

0.275 μg/mL (IC50)

BRafV600E

0.078 μg/mL (IC50)

c-Met

0.405 μg/mL (IC50)

EGFR (WT)

0.177 μg/mL (IC50)

PIM1

1.053 μg/mL (IC50)

分子量

444.49

Formula

C27H20N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-target kinase-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-target kinase-IN-8Rafc-Met/HGFRPimEGFRVEGFRApoptosisRaf kinasesPim kinasesEpidermal growth factor receptorErbB-1HER1Vascular endothelial growth factor receptorB-Raf V600Ec-MetPim-1VEGFR-2apoptosiscancerInhibitorinhibitorinhibit

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