2. Neuronal Signaling Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. Monoamine Oxidase Amyloid-β Mitochondrial Metabolism Apoptosis Reactive Oxygen Species (ROS) COX NF-κB
  4. Multitarget AD-IN-3

Multitarget AD-IN-3 是一种可穿透血脑屏障的神经保护剂。Multitarget AD-IN-3 能选择性抑制 MAO-B，其 IC50 为 4.42 μM， SI 为 18.12。Multitarget AD-IN-3 能清除活性氧 (ROS)。Multitarget AD-IN-3 能抑制 Aβ1-42 自聚集，并且能逆转 Aβ1-42 诱导的线粒体膜去极化并抑制细胞凋亡 (apoptosis)。Multitarget AD-IN-3 可用于神经系统疾病的研究，如阿尔茨海默病。

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Multitarget AD-IN-3

Multitarget AD-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

Multitarget AD-IN-3 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multitarget AD-IN-3 is a brain-penetrant neuroprotective agent. Multitarget AD-IN-3 can selectively inhibit MAO-B with an IC50 of 4.42 μM and a SI of 18.12. Multitarget AD-IN-3 can eliminate ROS. Multitarget AD-IN-3 Multitarget AD-IN-3 can inhibit Aβ1-42 self-aggregation and can reverse Aβ1-42-induced mitochondrial membrane depolarization and inhibit apoptosis. Multitarget AD-IN-3 can be used for the research of neurological disease, such as Alzheimer’s disease[1].

IC50 & Target[1]

MAO-B

4.42 μM (IC50)

MAO-A

80.21 μM (IC50)

COX

 

体外研究
(In Vitro)

Multitarget AD-IN-3 (10 μM) 在 LPS 刺激的 RAW 264.7 和 BV-2 细胞中，显著抑制 NO、TNF-α、IL-6 的产生，同时下调 COX-2 和 NF-κB 的表达[1]。
Multitarget AD-IN-3 (10 μM) 可显著降低 TBHP 诱导的 SH-SY5Y 细胞内 ROS 积累[1]。
Multitarget AD-IN-3 可与 Al3+、Cu2+、Fe2+、Zn2+ 发生螯合作用[1]。
Multitarget AD-IN-3 (25-50 μM, 24 h) 可浓度依赖性抑制 Aβ1-42 自聚集[1]。
Multitarget AD-IN-3 (10 μM, 18-24 h) 可逆转 Aβ1-42 诱导的 SH-SY5Y 细胞线粒体膜去极化，抑制凋亡，并提高细胞活力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Multitarget AD-IN-3 相关抗体:

Immunofluorescence[1]

Cell Line: SH-SY5Y cells
Concentration: 10 μM
Incubation Time: 18 h
Result: Increased the JC-1 red/green fluorescence ratio.
分子量

407.38

Formula

C19H17N7O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multitarget AD-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multitarget AD-IN-3Monoamine OxidaseAmyloid-βMitochondrial MetabolismApoptosisReactive Oxygen Species (ROS)COXNF-κBMAOβ-amyloid peptideAβAbetaCyclooxygenaseNuclear factor-κBNuclear factor-kappaBneuroprotective agentMAO-BAβ1-42COX-2mitochondrial membraneapoptosisAlzheimer’s diseaseRAW 264.7BV-2SH-SY5YInhibitorinhibitorinhibit

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