2. Neuronal Signaling Membrane Transporter/Ion Channel
  3. Cholinesterase (ChE) Calcium Channel
  4. Multitarget AD-IN-4

Multitarget AD-IN-4 (compound IIIj) 是一种多靶点导向配体 (MTDL)，能够同时抑制多种胆碱酯酶 (EeAChE IC50 = 0.157 μM，eqBuChE IC50 = 0.147 μM，hAChE IC50 = 1.551 μM，hBuChE IC50 = 2.152 μM)，具有抗氧化活性，提供神经保护作用，并抑制钙通道 (针对 Ca2+ 通道阻滞的 IC50 为 30.59 μM)。Multitarget AD-IN-4 可逆转小鼠模型中东莨菪碱 (HY-N0296) 诱导的遗忘症。Multitarget AD-IN-4 可用于阿尔茨海默病 (AD) 的研究。

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Multitarget AD-IN-4

Multitarget AD-IN-4 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Multitarget AD-IN-4 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Calcium Channel 亚型特异性产品:

查看所有亚型
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multitarget AD-IN-4 (compound IIIj) is a multitarget-directed ligand (MTDL), with the ability to simultaneously inhibit ChE enzymes (EeAChE IC50 = 0.157 μM, eqBuChE IC50 = 0.147 μM, hAChE IC50 = 1.551 μM, hBuChE IC50 = 2.152 μM), exhibit antioxidant activity, provide neuroprotection, and inhibit calcium channels (Ca2+ channel blockade: IC50 = 30.59 μM). Multitarget AD-IN-4 reverses Scopolamine (HY-N0296)-induced amnesia in a mouse model. Multitarget AD-IN-4 can be used for Alzheimer’s disease (AD) research[1].

IC50 & Target[1]

Calcium Channel

30.59 μM (IC50)

EeAChE

0.157 μM (IC50)

eqBCHE

0.147 μM (IC50)

hAChE

1.551 μM (IC50)

hBCHE

2.152 μM (IC50)

分子量

729.26

Formula

C39H45ClN6O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multitarget AD-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multitarget AD-IN-4Cholinesterase (ChE)Calcium ChannelCa2+ channelsCa channelsmultitarget-directed ligandantioxidant activityScopolamine-induced amnesiaAlzheimer’s diseaseInhibitorinhibitorinhibit

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目录号：
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