2. Others Neuronal Signaling
  3. Drug Derivative Cholinesterase (ChE) Monoamine Oxidase Amyloid-β
  4. Multitarget AD-IN-5

Multitarget AD-IN-5 (Compound 20) 是 9-Aminoacridine (HY-B1422) 的衍生物，是一种神经保护剂。Multitarget AD-IN-5 对 hAChE、hBChE、 MAO-A 和 hMAO-B 的 IC50 值分别为 0.614、0.448、3.73 和 1.55 μM。Multitarget AD-IN-5 能够减小 Aβ42 纤维的长度和直径，并减少单位面积内的纤维数量。Multitarget AD-IN-5 可用于阿尔茨海默病的研究。

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Multitarget AD-IN-5

Multitarget AD-IN-5 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

Multitarget AD-IN-5 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multitarget AD-IN-5 (Compound 20), 9-Aminoacridine (HY-B1422) derivative, is a neuroprotective agent. Multitarget AD-IN-5 shows IC50 values of 0.614, 0.448, 3.73 and 1.55 μM for hAChE, hBChE, hMAO-A and hMAO-B. Multitarget AD-IN-5 can reduce length and diameter of Aβ42 fibers, and decrease the number of fibers per unit area. Multitarget AD-IN-5 can be used for research of Alzheimer's disease[1].

IC50 & Target[1]

hAChE

0.614 μM (IC50)

hBCHE

0.448 μM (IC50)

hMAO-A

3.73 μM (IC50)

hMAO-B

1.55 μM (IC50)

体外研究
(In Vitro)

Multitarget AD-IN-5 对 SH-SY5Y 细胞的 CC50 值为 95 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Multitarget AD-IN-5 相关抗体:
分子量

417.72

Formula

C21H15Cl3N2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multitarget AD-IN-5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multitarget AD-IN-5Drug DerivativeCholinesterase (ChE)Monoamine OxidaseAmyloid-βDrug derivativeMAOβ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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目录号：
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