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    N-Acetyl-D-mannosamine  (Synonyms: N-Acetylmannosamine; ManNAc)

    目录号: HY-128850 纯度: 99.99%
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    N-Acetyl-D-mannosamine (ManNAc) 是一种具有口服活性的唾液酸 (Sialic Acid) 前体,可通过增加 IgG 的唾液酸化来预防高血压,有望用于心血管疾病研究。N-Acetyl-D-mannosamine 可激活食欲素神经元中的 hypocretin (HCRT) 基因表达及改善衰老引起的神经损伤,为神经疾病的研究提供了潜在的可能。

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    N-Acetyl-D-mannosamine Chemical Structure

    CAS No. : 3615-17-6

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    规格 价格 是否有货 数量
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    N-Acetyl-D-mannosamine 相关抗体

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    生物活性

    N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders[1][2][3][4][5].

    IC50 & Target

    Human Endogenous Metabolite

     

    体内研究
    (In Vivo)

    N-Acetyl-D-mannosamine (通过饮用水送服,浓度为 1%,每日一次,持续 16 周) 可以通过增加 IgG 糖链上的唾液酸化水平,在高脂饮食诱导的高血压小鼠模型中预防肥胖引起的高血压[3]
    N-Acetyl-D-mannosamine (通过饮用水送服 (4-6 mL),2 g/kg,每日一次 ,持续 12 周) 在通过基因敲入 (Gne p.M712T) 构建的 GNE 相关肌病 C57BL/6J 小鼠模型中,逆转肾脏和肌肉的唾液酸化降低[4]
    N-Acetyl-D-mannosamine (通过饮用水送服,浓度为 0.5 %,每日自由进食,共 8 周) 可以改善 6 月龄和 14 月龄 SAMR1 小鼠的突触传递效率和长期增强 (Long-Term Potentiation, LTP)[5]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    lass="cpd-mod-vv"> lass="cpd-vivo-list">
    Animal Model: High-fat diet-induced hypertension C57BL/6 mice model[2]
    Dosage: Dissolved in drinking water at a concentration of 1%
    Administration: Oral gavage (p.o.), once daily for 16 weeks
    Result: Inhibited high-fat diet-induced weight gain and increased the sialylation of IgG glycans.
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    Animal Model: Knock-in C57BL/6J mice model (Gne p.M712T) of GNE myopathy
    Dosage: 1 or 2 g/kg
    Administration: Administered via drinking water (4-6 mL daily), once daily for 12 weeks
    Result: Showed a significant decrease of proteinuria after only one week on the treatment (2 g/kg)
    分子量

    221.21

    Formula

    C8H15NO6

    CAS 号
    性状

    固体

    颜色

    White to off-white

    结构分类 lass="source-classify">
    初始来源 lass="source-classify">
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    溶解性数据 lass="ss-title solution-tit" id="solution-tit" style="font-style: normal">细胞实验:  lass="ss-vitro solution-vitro">

    H2O 中的溶解度 : 116.67 mg/mL (527.42 mM; 超声助溶)

    lass="stock-tit">
    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 4.5206 mL 22.6030 mL 45.2059 mL
    5 mM 0.9041 mL 4.5206 mL 9.0412 mL
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    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

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    lass="ss-title solution-tit" style="font-style: normal">动物实验: lass="ss-vivo" style="padding: 6px 0 7px 0;">
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    以下溶解方案,请直接配制工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

    • lass="invivo-step invivo-step-new"> lass="ss-vivo-order step-tit">方案 一 lass="ss-vivo-text ss-vivo-text-new">

      请依序添加每种溶剂: PBS

      Solubility: 25 mg/mL (113.01 mM); 澄清溶液; 超声助溶

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    纯度: 99.99%

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    N-Acetyl-D-mannosamine 相关分类

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    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
    储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.5206 mL 22.6030 mL 45.2059 mL 113.0148 mL
    5 mM 0.9041 mL 4.5206 mL 9.0412 mL 22.6030 mL
    10 mM 0.4521 mL 2.2603 mL 4.5206 mL 11.3015 mL
    15 mM 0.3014 mL 1.5069 mL 3.0137 mL 7.5343 mL
    20 mM 0.2260 mL 1.1301 mL 2.2603 mL 5.6507 mL
    25 mM 0.1808 mL 0.9041 mL 1.8082 mL 4.5206 mL
    30 mM 0.1507 mL 0.7534 mL 1.5069 mL 3.7672 mL
    40 mM 0.1130 mL 0.5651 mL 1.1301 mL 2.8254 mL
    50 mM 0.0904 mL 0.4521 mL 0.9041 mL 2.2603 mL
    60 mM 0.0753 mL 0.3767 mL 0.7534 mL 1.8836 mL
    80 mM 0.0565 mL 0.2825 mL 0.5651 mL 1.4127 mL
    100 mM 0.0452 mL 0.2260 mL 0.4521 mL 1.1301 mL

    * 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

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    Keywords:

    N-Acetyl-D-mannosamine3615-17-6N-Acetylmannosamine ManNAcEndogenous MetaboliteHigh-fat diet-induced hypertension mice modelKnock-in mice model (Gne p.M712T) of GNE myopathy,Inhibitorinhibitorinhibit

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