2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. N-Deacetylthiocolchicine

N-Deacetylthiocolchicine 是一种微管蛋白 (tubulin) 抑制剂，在 MDR 阴性的 MDA-MB 231 乳腺癌细胞中的 IC50 值为 2.2 nM。N-Deacetylthiocolchicine 通过与微管蛋白结合干扰微管组装，使细胞在细胞周期中停滞于有丝分裂期，发挥抗增殖活性。N-Deacetylthiocolchicine 有望用于恶性肿瘤的研究，如乳腺癌。

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N-Deacetylthiocolchicine

N-Deacetylthiocolchicine Chemical Structure

CAS No. : 2731-16-0

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N-Deacetylthiocolchicine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Deacetylthiocolchicine is a tubulin inhibitor with an IC50 value of 2.2 nM in MDR-negative MDA-MB 231 breast cancer cells. N-Deacetylthiocolchicine exerts antiproliferative activity by binding to tubulin to interfere with microtubule assembly, arresting cells in mitosis during the cell cycle. N-Deacetylthiocolchicine is promising for research of malignancies such as breast cancer[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 ED50
0.0077 μg/mL
Compound: 4
Cytotoxicity against human A549 cells after 2 days
Cytotoxicity against human A549 cells after 2 days
[PMID: 20542428]
A549 IC50
11 nM
Compound: DTCOLCH
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
[PMID: 34592435]
A549 IC50
24.1 nM
Compound: 3
Antiproliferative activity against human A549 cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by SRB assay
[PMID: 33465696]
BALB/3T3 IC50
15.4 nM
Compound: DTCOLCH
Cytotoxicity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Cytotoxicity against mouse BALB/3T3 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
[PMID: 34592435]
BALB/3T3 IC50
223 nM
Compound: 3
Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs by SRB assay
Antiproliferative activity against mouse BALB/3T3 cells incubated for 72 hrs by SRB assay
[PMID: 33465696]
CA46 IC50
38 μM
Compound: 6a
Inhibits the growth of the human Burkitt lymphoma CA46 cell
Inhibits the growth of the human Burkitt lymphoma CA46 cell
[PMID: 9083485]
DLD-1 IC50
1180 nM
Compound: 7
Cytotoxicity against human DLD1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human DLD1 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 30429975]
DU-145 ED50
0.0018 μg/mL
Compound: 4
Cytotoxicity against human DU145 cells after 2 days
Cytotoxicity against human DU145 cells after 2 days
[PMID: 20542428]
H9 EC50
0.013 μM
Compound: 10
Cytotoxicity against human H9 cells
Cytotoxicity against human H9 cells
[PMID: 1919593]
H9 IC50
0.013 μM
Compound: 10
Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen capture assay
[PMID: 1919593]
HCT-8 ED50
0.005 μg/mL
Compound: 4
Cytotoxicity against human HCT8 cells after 2 days
Cytotoxicity against human HCT8 cells after 2 days
[PMID: 20542428]
HeLa GI50
0.014 μM
Compound: 11a
Antiproliferative activity against human HeLa cells assessed as reduction in cell number incubated for 72 hrs
Antiproliferative activity against human HeLa cells assessed as reduction in cell number incubated for 72 hrs
[PMID: 30996805]
HepG2 GI50
0.018 μM
Compound: 11a
Antiproliferative activity against human HepG2 cells assessed as reduction in cell number incubated for 72 hrs
Antiproliferative activity against human HepG2 cells assessed as reduction in cell number incubated for 72 hrs
[PMID: 30996805]
IGROV-1 IC50
0.023 μM
Compound: 2
Antiproliferative activity against human IGROV1 cells assessed as growth inhibition after 72 hrs by Coulter counting analysis
Antiproliferative activity against human IGROV1 cells assessed as growth inhibition after 72 hrs by Coulter counting analysis
[PMID: 19833515]
KB ED50
0.0018 μg/mL
Compound: 4
Cytotoxicity against human KB cells after 2 days
Cytotoxicity against human KB cells after 2 days
[PMID: 20542428]
L1210 IC50
40 nM
Compound: 31
In vitro cytotoxicity against L1210 (murine leukemia) cells.
In vitro cytotoxicity against L1210 (murine leukemia) cells.
[PMID: 2299625]
LoVo IC50
10.3 nM
Compound: DTCOLCH
Antiproliferative activity against human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against human LoVo cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
[PMID: 34592435]
LoVo IC50
1020 nM
Compound: 7
Cytotoxicity against human LoVo cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 30429975]
LoVo IC50
16.9 nM
Compound: 3
Antiproliferative activity against human LoVo cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human LoVo cells incubated for 72 hrs by SRB assay
[PMID: 33465696]
MCF7 GI50
0.018 μM
Compound: 11a
Antiproliferative activity against human MCF7 cells assessed as reduction in cell number incubated for 72 hrs
Antiproliferative activity against human MCF7 cells assessed as reduction in cell number incubated for 72 hrs
[PMID: 30996805]
MCF7 IC50
14.2 nM
Compound: 3
Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by SRB assay
Antiproliferative activity against human MCF-7 cells incubated for 72 hrs by SRB assay
[PMID: 33465696]
MCF7 IC50
4200 nM
Compound: 3
Anti tumor activity on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment
Anti tumor activity on human breast cancer cell line MDR-positive MCF-7 ADRr after 72 hours of treatment
[PMID: 10602712]
MCF7 IC50
670 nM
Compound: 7
Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 30429975]
MCF7 IC50
9.5 nM
Compound: DTCOLCH
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 72 hrs by SRB assay
[PMID: 34592435]
MDA-MB-231 IC50
1260 nM
Compound: 7
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 30429975]
MDA-MB-231 IC50
2.2 nM
Compound: 3
Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment
Anti tumor activity on human breast cancer cell line MDR-negative MDA-MB 231 after 72 hours of treatment
[PMID: 10602712]
SK-BR-3 ED50
0.0016 μg/mL
Compound: 4
Cytotoxicity against human SKBR3 cells after 2 days
Cytotoxicity against human SKBR3 cells after 2 days
[PMID: 20542428]
SK-OV-3 IC50
1.3 nM
Compound: 7
Cytotoxicity against human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 30429975]
SK-OV-3 IC50
9.6 nM
Compound: 7
Cytotoxicity against arrested non-proliferative human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
Cytotoxicity against arrested non-proliferative human SKOV3 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
[PMID: 30429975]
分子量

373.47

Formula

C20H23NO4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N-Deacetylthiocolchicine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Deacetylthiocolchicine2731-16-0Microtubule/TubulinTubulinbreast cancer cellsmitosisInhibitorinhibitorinhibit

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