2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation
  3. nAChR Interleukin Related
  4. nAChR antagonist 2

nAChR antagonist 2 是一种选择性 nAChR 拮抗剂。nAChR antagonist 2 在非洲爪蟾卵母细胞中对包括人源 α9α10、α9 和 α7 在内的 nAChR 亚型表现出抑制活性，其 IC50 值分别为 16.0 nM、26.2 nM 和 336.3 nM。nAChR antagonist 2 能在纳摩尔浓度水平抑制 ATP 诱导的 IL-1β 释放。nAChR antagonist 2 可用于非阿片类镇痛药和免疫调节剂的相关研究。

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nAChR antagonist 2

nAChR antagonist 2 Chemical Structure

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nAChR antagonist 2 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

nAChR antagonist 2 is a selective nAChR antagonist. nAChR antagonist 2 inhibits nAChR subtype including hα9α10, hα9, and hα7 with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM, respectively, in Xenopus oocytes. nAChR antagonist 2 suppresses ATP-induced IL-1β release at nanomolar concentrations. nAChR antagonist 2 can be used for nonopioid analgesics and immunomodulators research[1].

IC50 & Target[1]

IL-1β

 

体外研究
(In Vitro)

nAChR antagonist 2 (compound 22) (300 pM-30 μM，处理 3 分钟) 可选择性抑制非洲爪蟾卵母细胞中表达的含 α9 亚基 nAChR 介导的乙酰胆碱诱发电流，其对 hα9α10、hα9 及 hα7 受体的 IC50 值分别为 16.0 nM、26.2 nM和 336.3 nM[1]。
nAChR antagonist 2 (100 pM 或 100 nM，处理 40 分钟) 在单核细胞 THP-1 的神经元型烟碱受体上同时发挥拮抗与激动功能[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

nAChR antagonist 2 相关抗体:

ELISA Assay[1]

Cell Line: THP-1 cells were primed with Lipopolysaccharide (HY-D1056) (1 μg/mL, 5 h), followed by 40 min of BzATP triethylammonium salt (HY-136254) (40 min)[1]
Concentration: 100 pM or 100 nM
Incubation Time: 40 min
Result: Efficiently antagonized the inhibitory effect of Ach at 100 pM.
Exhibted mild antagonistic effects at higher 100nM.
Effectively and significantly inhibited the BzATP (HY-136254)-induced release of IL-1β in the absence of ACh.
分子量

481.41

Formula

C23H32INO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

nAChR antagonist 2 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nAChR antagonist 2nAChR antagonist2nAChR antagonist-2nAChRInterleukin RelatedNicotinic acetylcholine receptorsILnAChR antagonistIL-1β releasenonopioid analgesicsimmunomodulatorsInhibitorinhibitorinhibit

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nAChR antagonist 2
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HY-180559
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