2. MAPK/ERK Pathway Stem Cell/Wnt
  3. MEK ERK
  4. Napyradiomycin B4

Napyradiomycin B4 是 Napyradiomycin 衍生物，可抑制 RANKL 诱导的 MEK-ERK 信号通路。Napyradiomycin B4 可减弱破骨细胞生成并防止实验性牙周炎中的牙槽骨破坏。

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Napyradiomycin B4

Napyradiomycin B4 Chemical Structure

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Napyradiomycin B4 相关抗体

Top Publications Citing Use of Products

查看 MEK 亚型特异性产品:

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Napyradiomycin B4 is a Napyradiomycin derivative, which inhibits the RANKL-induced MEK-ERK signaling pathway. Napyradiomycin B4 attenuates osteoclastogenesis and prevents alveolar bone destruction in experimental periodontitis[1].

体外研究
(In Vitro)

Napyradiomycin B4 (5 μM, 4 days) 抑制 RANKL 诱导的破骨细胞分化[1]。
Napyradiomycin B4 (5 μM, 4 days) 促进 Nrf2 相关基因的表达并抑制破骨细胞相关基因的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Napyradiomycin B4 相关抗体:

Immunofluorescence[1]

Cell Line: BMMs
Concentration: 1-5 μM
Incubation Time: 4 days
Result: Revealed no evidence of F-actin ring.

Real Time qPCR[1]

Cell Line: BMMs
Concentration: 1-5 μM
Incubation Time: 4 days
Result: Reduced mRNA expressions of Nfatc1, Acp5, Dcstamp, Ctsk, and Mmp9.
Promoted mRNA expressions of Nrf2, Nqo1 and HO1.
体内研究
(In Vivo)

Napyradiomycin B4 (2-12 mg/kg，腹腔注射，6 天) 对破骨细胞介导的骨质流失具有保护作用，在 C57BL/J6 小鼠模型中通过抑制破骨细胞形成来防止牙周骨质破坏，且无明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ligature-induced periodontitis in C57BL/J6 mice model[1]
Dosage: 2-12 mg/kg
Administration: i.p. for 6 days
Result: Prevented the alveolar bone resorption and bone loss with high dose, inhibited osteoclast formation.
分子量

533.87

Formula

C25H31Cl3O6
结构分类
初始来源

marine-derived Streptomyces species
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Napyradiomycin B4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Napyradiomycin B4Napyradiomycin B 4Napyradiomycin B-4MEKERKMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesperiodontitisC57BL/J6 miceBMMYP127Streptomycesbone diseaseInhibitorinhibitorinhibit

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目录号：
HY-N12740
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