2. Immunology/Inflammation
  3. CD20
  4. NAV006

NAV006 是一种抗 CD20 抗体 Rituximab (HY-P9913) 变体，其与 CD20 的结合 Kd 为 30.5 nM。NAV006 与 CA125 的相互作用减弱，并表现出增强的抗体依赖性细胞毒性 (ADCC) 和补体依赖性细胞毒性 (CDC) 活性。NAV006 对淋巴瘤具有抗肿瘤活性。NAV006 可用于非霍奇金淋巴瘤的研究。

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NAV006

NAV006 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

NAV006 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NAV006 is an anti-CD20 antibody variant of Rituximab (HY-P9913) with a Kd of 30.5 nM to CD20. NAV006 exhibits reduced interaction with CA125 and demonstrates enhanced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activity. NAV006 displays antitumor activity against lymphoma and can be used in research on non-Hodgkin lymphoma[1][2].

反应种属

Human
IC50 & Target

CD20

30.5 nM (Kd)

体外研究
(In Vitro)

NAV006 (0.78-100 nM) 以剂量依赖的方式特异性地与 CD20 阳性 Ramos 细胞结合 (Kd = 30.5 nM)[1]。
NAV006 与母体 Rituximab (HY-P9913) 相比，在免疫抑制剂 CA125 存在的情况下，能够对 Daudi 靶细胞介导更强大的 Fc 受体依赖性细胞毒活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NAV006 相关抗体:
体内研究
(In Vivo)

NAV006 (1 mg/kg；腹腔注射) 在荷人淋巴瘤 Raji 细胞的 NCG 小鼠中发挥抗肿瘤活性 (肿瘤生长抑制率达 95%)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

931  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NAV006 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAV006NAV 006NAV-006CD20complement-dependent cytotoxicityCA125/MUC16human lymphoma Raji cellsCD20-positive cellshuman CD20non-hodgkin lymphomaCDChuman lymphoma modelsADCCNCG miceantibody-dependent cellular cytotoxicityreconstituted CA125/MUC16CA125Inhibitorinhibitorinhibit

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产品名称：
NAV006
目录号：
HY-P991902
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