2. Apoptosis
  3. Apoptosis
  4. NC-001

NC-001是一种选择性的凋亡 (apoptosis) 诱导剂，靶向肾近端小管细胞和肾癌细胞。NC-001 在透明细胞肾细胞癌 (CCRCC) 的异种移植模型中，能抑制肿瘤的生长。NC-001 有望用于转移性肾细胞癌的研究。

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NC-001

NC-001 Chemical Structure

CAS No. : 1237540-68-9

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NC-001 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NC-001 is a selective apoptosis inducer targeting renal proximal tubular cells and renal cancer cells. NC-001 inhibits tumor growth in clear cell renal cell carcinoma (CCRCC) xenograft models. NC-001 is promising for research of metastatic renal cell carcinoma[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RPMI-8226 IC50
0.14 μM
Compound: 3, NC-001
Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
[PMID: 25006746]
RPMI-8226 IC50
0.37 μM
Compound: 3, NC-001
Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
[PMID: 25006746]
RPMI-8226 IC50
> 10 μM
Compound: 3, NC-001
Inhibition of proteasome subunit beta-2c/i in human RPMI8226 cells by fluorescent densitometry
Inhibition of proteasome subunit beta-2c/i in human RPMI8226 cells by fluorescent densitometry
[PMID: 25006746]
RPMI-8226 IC50
> 10 μM
Compound: 3, NC-001
Inhibition of proteasome subunit beta-5c/i in human RPMI8226 cells by fluorescent densitometry
Inhibition of proteasome subunit beta-5c/i in human RPMI8226 cells by fluorescent densitometry
[PMID: 25006746]
Raji IC50
0.045 μM
Compound: 3, NC-001
Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
[PMID: 25006746]
Raji IC50
0.088 μM
Compound: 3, NC-001
Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
[PMID: 25006746]
分子量

535.64

Formula

C25H41N7O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NC-001 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NC-0011237540-68-9NC001NC 001Apoptosisapoptosis inducerrenal proximal tubular cellsCCRCCInhibitorinhibitorinhibit

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目录号：
HY-120569
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