2. Anti-infection
  3. Beta-lactamase Bacterial
  4. NDM-1-IN-11

NDM-1-IN-11 是一种强效的 NDM-1 共价抑制剂，IC50 值为 1.12 μM，其作用机制是通过与酶形成 Se-S 键。NDM-1-IN-11 与 Meropenem (HY-13678) 联用在体内和体外模型中均能有效抑制产 NDM-1 大肠杆菌的生长。NDM-1-IN-11 可用于研究由 NDM-1 引起的细菌耐药性问题。

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NDM-1-IN-11

NDM-1-IN-11 Chemical Structure

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NDM-1-IN-11 相关抗体

Top Publications Citing Use of Products

查看 Beta-lactamase 亚型特异性产品:

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Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NDM-1-IN-11 is a potent covalent NDM-1 inhibitor with an IC50 of 1.12 μM, which acts by forming a Se-S bond with the enzyme. NDM-1-IN-11 effectively suppresses the growth of NDM-1-producing E. coli in both in vivo and in vitro models when combined with Meropenem (HY-13678). NDM-1-IN-11 can be used for addressing NDM-1 driven bacterial resistance[1].

IC50 & Target[1]

NDM-1

1.12 μM (IC50)

体外研究
(In Vitro)

NDM-1-IN-11 (compound 27k) (4 小时) 与 Meropenem 表现出强效的协同作用，对产 NDM-1 的 Carbapenem 耐药肠杆菌科细菌 (CRE) 分离株的最低抑菌浓度 (MIC) ≤32 µg/mL[1]。
NDM-1-IN-11 (0-64 μg/mL；0-8 小时) 可恢复 Meropenem 对产生 NDM-1 的耐 Carbapenem 大肠杆菌 (菌株 ZJ487 和 TG-1) 的活性[1]。
NDM-1-IN-11 (0-64 μg/mL；6 h) 在 HEK-293T 和 RAW264.7 细胞中未表现出明显的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NDM-1-IN-11 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HEK-293T, RAW264.7
Concentration: 0, 4, 8, 16, 32, 64 μg/mL
Incubation Time: 6 h
Result: Showed no significant cytotoxicity in HEK-293T and RAW264.7 cells.
体内研究
(In Vivo)

NDM-1-IN-11 (10 mg/kg，皮下注射，每 12 小时一次，共 3 次) 与 Meropenem 联合使用可有效抑制小鼠体内 E. coli ZJ487 的细菌载量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c (6-8 weeks old, 18-22 g) intraperitoneally injected with E. coli ZJ487[1]
Dosage: 10 mg/kg
Administration: s.c., every 12 hours, 3 doses
Result: Did not significantly reduce bacterial counts in the liver and spleen of infected mice compared to the control group alone.
Resulted in a marked reduction in bacterial counts in the liver and spleen of infected mice when combined with Meropenem (10 mg/kg).
分子量

519.38

Formula

C26H17FN2O4Se
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NDM-1-IN-11 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDM-1-IN-11Beta-lactamaseBacterialβ-lactamasebacterial resistanceinhibitorsEbselenNDM-1Se-S covalent bondInhibitorinhibitorinhibit

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目录号：
HY-179618
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